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sorry, I misread your post . Well, to make it the most "loudiest", ehmmm, raise the volume and lower the rest. 
Compressing the lead with a ratio of 4:1, attack 5 ms and a release of 10 ms should work fine most of the time. ( you should find a good threshold level depending on the volume of the lead )
If some instruments clash with the lead, use panning or EQ to make the lead stand out more.
You can also layer the lead to make it more bigger in the mix.
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