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-- Design vs. Arbitrary
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| Originally posted by Knight Rider The fact that evolutionist claims based on biogeography are myths devoid of any scientific evidence clearly emerge on inspection their claims about palaeontology. The fossil record clearly reveals that the idea that living things spread by evolving is a myth. |
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| Originally posted by DrUg_Tit0 I must also say that you are totally incorrect when you keep insisting that evolution is random. It is not random. |
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| Originally posted by Knight Rider Tell me, if it is not deliberate, then what is it ? |
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| The weakness of evolution is that it is based on a 'random' process - chance. |
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| This is where I disagree with you. If design (which is always deliberate) relies on chance, then it cannot be a design. The evidence we observe may well be an aspect of 'deliberate' design (not chance) which we have yet to comprehend. |
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| Evolution: single-gene speciation by left-right reversal. Ueshima R, Asami T. Nature. 2003 Oct 16;425(6959):679. Summary: A single gene gives rise to the mirror-image form of a snail's body plan, which could become established as a different species if mating is prevented between snails of different chirality by genital mismatch. Here we use molecular phylogeny to demonstrate the parallel evolution of reversal between left and right lineages of the Japanese land snail Euhadra. We find that the different mirror-image forms have evolved in favour of the genetically dominant handedness as a result of single-gene speciation. http://www.nature.com/cgi-taf/DynaP...425679a_fs.html |
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| http://www.nature.com/cgi-taf/DynaP...ml&filetype=pdf Abstract: Microorganisms have been mutating and evolving on Earth for billions of years. Now, a field of research has developed around the idea of using microorganisms to study evolution in action. Controlled and replicated experiments are using viruses, bacteria and yeast to investigate how their genomes and phenotypic properties evolve over hundreds and even thousands of generations. Here, we examine the dynamics of evolutionary adaptation, the genetic bases of adaptation, tradeoffs and the environmental specificity of adaptation, the origin and evolutionary consequences of mutators, and the process of drift decay in very small populations. |
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| This simple approach, subsequently perfected by many investigators and extended over the years to many different systems, led eventually to the general conclusion that indeed mutations are not directed by the selective needs of the organism, or in evolutionary lingo, that they are �random with regard to fitness�. These results were critical in the development of the neo-darwinian New Synthesis. And there sat this �orthodoxy�, this �dogma�, for 45 years, so routinely and extensively confirmed in bacteriology and toxicology labs that everyone took it for granted, until 1988. In that year, a paper was published in Nature, one of the very top science journals, by John Cairns, a very well known geneticist, and his collaborators [2]. Titled �The origin of mutants�, the paper described an experiment not much unlike Luria�s: in this case, mutants were selected for their ability to re-activate a crippled gene that allowed them to metabolize the sugar lactose, the only source of energy avaliable on the selection plates. However, unlike phage selection, starvation does not kill the bacteria immediately, but allows them a certain time to try to escape their dire situation. To everyone�s surprise, Cairns reported that in these conditions, besides a number of early-growing mutant colonies that followed the expected Luria-Delbruck distribution, he could observe many late-growing resistant clones with a much more homogeneous distribution, which indicated that the mutations followed, and not preceded, the exposure to selection. Even more strikingly, when mutations at a different gene were analyzed in the lactose revertants, no mutations were observed. In other words, the mutations appeared to be �directed� by the selection process specifically to the gene under selection. Cairns and co-workers concluded therefore that at least in some cases, mutations could be specifically directed by selective pressures. Bam. The door was opne for teleology. Adieu, "darwinist orthodoxy". Cairns even "brazenly" raised the specter of possible Lamarckian hereditary mechanisms � one cannot get more heretic than that! It�s not that the paper flew below the radar � everybody understood its implications. In the same issue of Nature, Franklin Stahl, another one of the founding fathers of bacterial genetics, endorsed its conclusions and ventured his own model of how directed mutations may happen [3]. In the following weeks, several letters about Cairns� findings were published in the same journal, most of them raising questions with the experimental design. For instance, it turns out that, for experimental reasons, the gene under selection was located not on the main bacterial chromosome, but on a separate genetic element called a plasmid; some possible implications of this positioning for the mutation process had escaped Cairns. Others argued that his selection of �control� non-selected gene was not ideal, also based on some genetic considerations regarding that gene�s functional properties. No one called for Cairns� metaphorical head, no one argued how Nature could have dared publishing anti-darwinian material. In fact, bacterial geneticists all over the world set out to investigate the new claims in their own labs. Cairns' basic observations were throroughly replicated, ruling out basic artifacts, and several investigators set up different experimental models to test the principle, and also obtained results suggesting "directed" mutations. From the skeptic side, alternative mechanistic explanations for the �directed� mutation claim were tested, which ultimately confirmed that the new phenomena fell within the darwinian framework. Although its conclusions were often criticized on an evidence basis, Cairns� paper not only was not suppressed, but was directly referenced in hundreds of articles (497 to date, accorsding to the ISI Citation Index). The back-and-forth papers and scientific correspondence in major journals make for excellent (and often entertaining, if that's your kind of thing) reading on the matter [4]. Within a few years, evidence accumulated for non-teleological models of mutation. By 1998, essentially everyone in the field, including Cairns and his closest collaborators, agreed that the original observation did not reflect �directed� mutations, which by that time had been re-baptized with the less loaded term "adaptive mutations" [5, 6]. Nevertheless, several interesting features of bacterial biology had been discovered in the process. One alternative model for the observations proposes that starved bacteria enter a �hypermutable� state , either by virtue of a specific genetic �rescue� program, or as a result of breakdown of normal cellular control mechanisms [7]. In this state, high levels of mutations are introduced throughout the bacterial genome, but selection for specific mutants makes it appear as if the environmental conditions preferentially targeted mutations to the selected gene. Importantly, this mechanism has relevance for the onset of bacterial resistance to antibiotic drugs, and possibly to certain cellular states involved in cancer development [5]. In another novel mechanism which has been observed, a multiplication of the copies of the crippled gene (�amplification�) is first favorably selected because it leads to a small but detectable increase in its product�s minimal activity [8]. This massive gene amplification makes for better chances of mutation, and when these occur the extra gene copies become a burden, and are eliminated by selection. The final result is the appearance of highly targeted mutations. Research on all these mechanisms is actively ongoing [9]. http://www.pandasthumb.org/pt-archives/000104.html |
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| Remember, around 70 yrs ago scientists were adamant that the atom was the smallest particle known to man. This supposed fact was taught in schools. Point being, that science has been wrong in the past, and as you say, given time, fresher evidence emerges in anticipation that we, as the human race, may understand the truth (fact) one day. |
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| Complete nonsense I'm afraid. The probabilities of sustaining simple life exceed the realms of plausibility and enter absurdity. |
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| I used the machine example to illustrate the sheer size of the numbers we are dealing with. |
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| With the availability of fast, powerful computers and computer simulation techniques, even engineers (the prototypical intelligent designers!) are using the creative powers of natural selection to aid them in their design efforts. The technique of "genetic algorithms", pioneered by computer scientist John H. Holland at the University of Michigan, simulates the mechanism of Darwinian evolution, involving mating, genetic recombination, reproduction, selection and mutation to design jet engines, integrated circuit chips, scheduling work in a busy machine shop, operating gas-pipeline pumping stations and recognizing patterns. 1989. "Natural Selection for Computers" Science News 136(22); 346-348 (November 25) |
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| Then why call it 'random' selection ? |
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| Why do the text books (certainly the ones I have read) refer to evolution as a process of random selection ? Unless of course this is an example of how the theory of evolution is evolving. |
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I can accept a model which permits intelligent design to adapt to dynamic surroundings, merely because the system in question is designed to do so. One may argue that evolution (random selection/chance) plays an active role in the process of adaptation based on observable evidence. We are misunderstood, perhaps. There is that chance. ![]() |
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| Either way, there is a fundamental and crucial difference between the two methodologies. Chance is probability, where as design is certainty. |
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PS : No need to apologise about your view. You are entitled to it and users should respect that. |
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| Originally posted by MisterOpus1 Well yes, there is an explanation - a mutation can indeed create new, novel features, as well as add, subtract, or duplicate already existing ones. It's entirely up to natural selection, however, to divy up the ones that are more or less advantageous to that organism and passes that down to generations with the ones that are more or less harmful to that organism where consequently they do not get passed down. The nylon bacterial bug, for example, produced a brand new novel feature that did not exist within the bacterial organism before. Or, take a mutation that increases both the bone length and density: http://content.nejm.org/cgi/content/short/346/20/1513 That would certainly qualify, would it not? Here's some more papers worth looking up on PubMed: There's literally thousands of examples of mutations giving rise to brand new novel features. |
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| Originally posted by Dervish Could be said that perhaps old redundant organs mutate into new useful ones? But it is just the way that hugely random mutations would need to build upon one another to create anything complex. |
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| Originally posted by Dervish Thats not an explaination for a whole new complex organ though. |
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| Mutations have pivotal functions in the onset of genetic diseases and are the fundamental substrate for evolution. However, present estimates of the spontaneous mutation rate and spectrum are derived from indirect and biased measurements. For instance, mutation rate estimates for Caenorhabditis elegans are extrapolated from observations on a few genetic loci with visible phenotypes and vary over an order of magnitude. Alternative approaches in mammals, relying on phylogenetic comparisons of pseudogene loci and fourfold degenerate codon positions, suffer from uncertainties in the actual number of generations separating the compared species and the inability to exclude biases associated with natural selection. Here we provide a direct and unbiased estimate of the nuclear mutation rate and its molecular spectrum with a set of C. elegans mutation-accumulation lines that reveal a mutation rate about tenfold higher than previous indirect estimates and an excess of insertions over deletions. Because deletions dominate patterns of C. elegans pseudogene variation, our observations indicate that natural selection might be significant in promoting small genome size, and challenge the prevalent assumption that pseudogene divergence accurately reflects the spontaneous mutation spectrum. |
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| That is single gene mutations which do not, as far as I can see create whole new organs. Yes they can dublicate given organs or change organs, or production of certain chemicals or structures. Which is very different to incremental changes. |
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| But how for example would the eye developed? Thats more what I mean. Could be said that perhaps old redundant organs mutate into new useful ones? But it is just the way that hugely random mutations would need to build upon one another to create anything complex. |
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| Originally posted by Shakka If the new functionality derived from said mutation is indeed a new, useful function, how can one say that the mutation was, in fact, random? |
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| It would seem that since the resulting new functionality serves a purpose, that the mutation was not a matter of chance so much as it was about hitting a critical point during mitosis that finally moved the needle enough to cause a specific, non-random mutation to finally occur. |
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| Originally posted by MisterOpus1 Well logically speaking, just because something beneficial occurs randomly doesn�t entail that such an event would not be random. But genetically speaking, the random process only occurs at first � mutation. The selective process proceeding the random mutation process is nature�s effective filter in weeding out the deleterious or harmful mutations from the beneficial ones that ultimately give rise to increased fitness levels for a given population. Well mitosis doesn�t have much to do with it really, but I do understand what you�re saying. There is no �critical� moment involved here really � IOW there is no known directed mechanism involved. No evidence has shown any directed mutation events occurring, and as I�ve outlined earlier the opposite actually occurs (random mutation). |
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| Originally posted by Shakka Hence humanity's only other primary, logical conclusion--that God did it. Right? Dude, I am so not involved in this discussion for reasons mentioned on page 1. I only threw a comment in there on a whim. |
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| Originally posted by MisterOpus1 Oh you know you wanna be involved in this geeky biology shit. You sooooo want to... |
I don't see what creationism has to do with this, MisterOpus1 ? I made it perfectly clear that I did not want to bring divinity into this thread.
The fact is that one cannot deny that evolution is based on a 'random' process. The aim of my first question was just that, either deliberate or chance, a case for absolute conditioning. For you to suggest that design stems from chance is quite simply the most laughable piece of text I have ever read on the internet. Mind you, I could suggest that you have little or no understanding of probability as a subject, so it balances out.
If I wish, I could explain my belief and present irrefutable evidence, not circumstantial. But you see it's a vicious circle. I'm not here to prove my beliefs, neither are you. I�m not here to influence your beliefs, neither are you. I�m not here to alter your beliefs, neither are you. Hence, why I am not here to present my case.
Our brief chat was interesting while it lasted.
Oh - If the theory of evolution has been evolving for over 150yrs, it brings complete new meaning to clutching straws. 
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| Originally posted by Knight Rider I don't see what creationism has to do with this, MisterOpus1 ? I made it perfectly clear that I did not want to bring divinity into this thread. |
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| The fact is that one cannot deny that evolution is based on a 'random' process. |
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| In any case, again I don't deny that chance, or mutation is part of the equation. |
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| The aim of my first question was just that, either deliberate or chance, a case for absolute conditioning. For you to suggest that design stems from chance is quite simply the most laughable piece of text I have ever read on the internet. |
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| What you�re implying is that something created via the evolutionary mechanisms, i.e. mutation and natural selection, is not �design�. I stated that evolutionary mechanisms explain things designed, or to be more precise, irreducibly complex, quite well. Take for instance the nylon bug: http://www.nmsr.org/nylon.htm Here we have a bacteria developing a complex novel feature � digesting nylon. This is explained quite well via the evolutionary mechanism. So I believe you�re getting tripped up on the definition of �design�. It is merely a descriptive, more or less. The heart of the matter is whether or not that design was created deliberately via a Designer or Designer mechanism (which hasn�t been depicted in any way), or not-so-deliberately via mutation and natural selection. You continue to imply evolution as CHANCE only � what you are leaving out is its very own SELECTIVE engine � natural selection. Therefore, evolution is not just CHANCE alone. |
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| Mind you, I could suggest that you have little or no understanding of probability as a subject, so it balances out. |
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| If I wish, I could explain my belief and present irrefutable evidence, not circumstantial. |
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| But you see it's a vicious circle. I'm not here to prove my beliefs, neither are you. I�m not here to influence your beliefs, neither are you. I�m not here to alter your beliefs, neither are you. Hence, why I am not here to present my case. |
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| I do not accept evolution as a plausible answer to our existence. The idea of 'chance' playing a role in the subsistence and balance of life is quite frankly, repugnant. �So why the thread ? Well, I�m interested in what other users may have to say on the subject of 'design' in nature. I've read a few Evolution / Creation threads, but none of them seem to address 'design' as a plausible concept of life. Personally, neither of the two can be integrated. It�s one or the other. 'Design' advocates a predetermined state, where as 'chance' is based on probability, guess work, hit 'n' miss, not knowing the outcome; the complete opposite of design. (Therefore creating an imbalance) In simple terms, are we the result of design, or do we stem from randomness ? Are the days of evolution numbered ? |
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| Our brief chat was interesting while it lasted. |
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Oh - If the theory of evolution has been evolving for over 150yrs, it brings complete new meaning to clutching straws. |
I love gravity. It really helps me stay grounded. But seriously folks.
In all honesty, since the prior discussion was about to go nowhere or get ugly...I think the formula for gravitational pull is pretty cool. It's one of those "universal-ish" equations, right? where X=n(yz)/r^2 and n represents some off-the-wall constant that makes you wonder. I mean 6.67x10^-11? What the hell is that the equivalent of, a flea fart in a vaccum?...Very Newtonian, though I guess Einstein didn't get his grubby little hands caught up so much in gravity since he was so busy with sticking his dick in an electrical socket and all...
Some other favorite "constants":
The mass on an electron: 9.11 x 10^-31 Kg. Let me just pull up my handy-dandy Health-O-Meter and weigh this baby...
e: 2.71828182846. Good ole Euler's number. WTF were you smoking at the time, Euler? A transcendental number?
Seriously. If I'm gonna have "constants" in my life, I'd rather it be a whole number interger like 1 or a perfect square like 81 or something. Sheesh!
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| You directly stated an assertion that you do not accept evolution as a plausible answer. I directly refuted that assertion with evidence. |
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| Originally posted by Knight Rider If you say so. I do not believe I have rejected the notion of mutation. I adhere to the notion that evolution is random since it is based on atleast one random mechanism. The point which has risen from this thread is of amalgamation between probability and certainty. Is such a contradicting combination possible in the subsistence of life ? One cannot answer a question like that with 'evolution'. One has to understand the principles behind design and chance prior to tackling/answering (what I feel to be) an important question. The fact is that scientists with basic understanding of probability may perceive and process observational data quite differently to those who specialise in probability (That's just an example, it works both ways). Then, would one not agree, that a chance exists for scientists to have misunderstood observational evidence ? |
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My argument is that the 'system' can only exist on absolute conditioning. It�s either/or, not both. |
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| Originally posted by Shakka I love gravity. It really helps me stay grounded. But seriously folks. In all honesty, since the prior discussion was about to go nowhere or get ugly...I think the formula for gravitational pull is pretty cool. It's one of those "universal-ish" equations, right? where X=n(yz)/r^2 and n represents some off-the-wall constant that makes you wonder. I mean 6.67x10^-11? What the hell is that the equivalent of, a flea fart in a vaccum?...Very Newtonian, though I guess Einstein didn't get his grubby little hands caught up so much in gravity since he was so busy with sticking his dick in an electrical socket and all... ![]() |
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| Some other favorite "constants": The mass on an electron: 9.11 x 10^-31 Kg. Let me just pull up my handy-dandy Health-O-Meter and weigh this baby... |
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| e: 2.71828182846. Good ole Euler's number. WTF were you smoking at the time, Euler? A transcendental number? Seriously. If I'm gonna have "constants" in my life, I'd rather it be a whole number interger like 1 or a perfect square like 81 or something. Sheesh! |
Heh. I was joking for the most part, but those are some good points. On the e equation--what does the "i" stand for again?
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| In systems with very large amounts of numbers, chance converges towards certainty. When you have an infinite amount of numbers, then chance is exactly equal to certainty. |
Woops--forgot one.
Planck's constant, denoted h, is a physical constant that is used to describe the sizes of quanta. It plays a central role in the theory of quantum mechanics, and is named after Max Planck, one of the founders of quantum theory. It has a value of approximately
h=6.6260693(11)*10^{-34}J(s)
Just found a nice list of 'em Wikipedia is great
This stuff used to fascinate me!
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| Originally posted by Knight Rider I didn't ask for convincing evidence and you certainly weren't compelled to provide it. |
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You need to learn to take it easy, MisterOpus1. |
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| Originally posted by Knight Rider OK, so lets assume that chance converges towards certainty and we substitute certainty with a 'target'. This target must be hit by means of a random mechanism (chance). The probability of attaining 100 amino acids in the correct sequence is in excess of 10^100. Design will achieve this task in one attempt, where as chance, as you have suggested, will hit the target 'eventually'. |
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| Remember, the correct sequence is required before the biological component is functional. i.e the mechnism of chance must hit the target on more than one occasions before a functioning biological cell (which sustains life) is attained. Hence the difference between probable and improbable. |
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| The emergence of a new function in a DNA or protein sequence is supposedly advantageous and is commonly believed to have occurred by advantageous mutations. However, acquiring a new function may require many mutational steps, and a point that needs emphasis is that the early steps might have been selectively neutral because the new function might not be manifested until a certain number of steps had already occurred. Li WH (1997) Molecular Evolution. Sinauer Associates, Sunderland, MA, p.427 |
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| Originally posted by Shakka Heh. I was joking for the most part, but those are some good points. On the e equation--what does the "i" stand for again? |
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| Originally posted by Knight Rider OK, so lets assume that chance converges towards certainty and we substitute certainty with a 'target'. This target must be hit by means of a random mechanism (chance). The probability of attaining 100 amino acids in the correct sequence is in excess of 10^100. Design will achieve this task in one attempt, where as chance, as you have suggested, will hit the target 'eventually'. Remember, the correct sequence is required before the biological component is functional. i.e the mechnism of chance must hit the target on more than one occasions before a functioning biological cell (which sustains life) is attained. Hence the difference between probable and improbable. |
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| A Designer would achieve this if we only saw evidence of Him doing so. Why is there no observed, verifiable evidence of a Designer doing this? |
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