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-- Chewing E's
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Posted by drizzt81 on Nov-24-2003 20:49:

1. i know someone who has chewed one once, and his mouth wasn't numb, but it tasted like shit, so he said.

2. YAY! we are back on shoving things up ones' arse.. (you know we germans are ALL ABOUT THE ARSE!!!)


Posted by xKaoSx on Nov-24-2003 20:57:

quote:
Originally posted by drizzt81
1. i know someone who has chewed one once, and his mouth wasn't numb, but it tasted like shit, so he said.

2. YAY! we are back on shoving things up ones' arse.. (you know we germans are ALL ABOUT THE ARSE!!!)


Yea- it's called plugging- Never done it before myself- no interest- but its supposed to dissolve slower and have a more even roll so you dony peak out so fast.


Posted by neoh on Nov-24-2003 21:13:

quote:
Originally posted by mezzir
um...correct me if i'm wrong, but did you just quote and respond to yourself?


I think he took a little too much of the stuff.


Posted by infinity HiGH on Nov-24-2003 21:15:

I couldn't chew E...I dunno, I hate the taste and want to wash it down as fast as possible.


Posted by Mike_B on Nov-24-2003 21:23:

agreed, taste so bitter and sick. I always have something to wast it down with.


Posted by neoh on Nov-24-2003 21:26:

Talking

chewing E makes you high much quicker, this way the pill doesent desolve in your stomach. The last time I chewed it, I had a chemical burn on my tongue. (and you want to put that in your stomach?) - and yeah, the taste is nasty. The pills almost taste spicy, maybe it was just the pills I always get, but.. as for the numbness in the mouth, I think if you chewed it... and I dont know, swished it in your mouth before swallowing, the walls of your mouth would be coated, and the numbness is from the drug settling through the wall of your cheeks.

and, I got a chemical burn on my tongue from chewing it, there's no way that little thing is going in my ass.

exit only. yield to the left, ah thank you.



- neoh


Posted by Mike_B on Nov-24-2003 21:34:

ok let's clear this up, first of all. MDMA cotact with skin does nothing. The feelings you get from an E buzz comes not from MDMA, but from the serotonin relesed from serotonin neurons in your brain. MDMA acts like, lets say a doorman, causing the neurons to release large if not all the serontonin into your synapse, rather then the usual amount your body uses, This is what makes you feel good, the downer is caused by lack of serotonin left in your body, because you body can't produce it fast enough. hense why you feel emotionless or depressed after. So why would e in his mouth make him numb, i dunno. But im pretty sure it must of been something else or just an affect that would normally happen anyways. For example, i know i tend to chew my cheeks and grind my teeth(and its numb so i don't always notice) neer the end if im not chewing gum or something.

Have you ever had these same symptomes when you ingested it normally. If so could just be a side affect for you. If not then i dunno, may have been another drug


Posted by butterfly on Nov-24-2003 21:42:

quote:
Originally posted by dancingpixie
http://www.ecstasydata.org



omg - in one of those pills the only active was lidocaine. that is really stupid! lidocaine is just an anesthetic and it is also toxic. it's amazing what people put in their bodies...


Posted by UWM on Nov-24-2003 22:10:

Yeah and some of the other ones that are 4 parts caffeine to one part speed ... how wonderful


Posted by butterfly on Nov-24-2003 22:20:

quote:
Originally posted by UWM
Yeah and some of the other ones that are 4 parts caffeine to one part speed ... how wonderful


i'd rather take speed than e. (if i was to take anything at all)


Posted by jdjd on Nov-24-2003 23:13:

anybody know the shelf life of e??


Posted by moncster on Nov-24-2003 23:46:

DON'T CHEW, PARACHUTE.


Posted by TidyAL on Nov-25-2003 00:04:

DONT CHEW THEY TASTE GASH!


Posted by DjGrl2000 on Nov-25-2003 00:05:

If you're shoving pills in your penis and up your ass, I think you have some major drug issues you need to deal with.


Posted by TidyAL on Nov-25-2003 00:08:

omg penis


Posted by daffodil on Nov-25-2003 00:41:

quote:
Originally posted by Mike_B
k i dunno where your getting your info. But stamps really don't mean much. Someone producing the pills makes one batch and puts a stamp on it. This may last like 3months tops, then he's out
he's gotta make more, the next one regardless if he puts the same stamp on it will probably not be 100% the same. And that's even if he uses the same formula and decides to put in the same mixtures of drugs and so on, which he probably wont. And another thing. look at the size of the pill you are taking. its very small. about 125milligrams. and that's a big pill too. coke most ppl might do like half a gram to one gram a night, easy. And the buzz on coke really only last about 30minutes, and E buzz last like 4-6 hours depending on how you take it. So once again. Explain to me how you find a good pill of e with coke in it. Makes NOOOOOOOOOOOO SENCE


i agree with you. i was just passing on information and playing a bit of devil's advocate.


Posted by DJ-Fuq on Nov-25-2003 01:53:

quote:
Originally posted by Mike_B
The feelings you get from an E buzz comes not from MDMA, but from the serotonin


Its a bit more complicated than that.
MDMA binds at the serotonin, norepinephrine (noradrenaline), dopamine, and acetylcholine receptors, and at the serotonin and dopamine transporters (Rivas-Vazquez, Delgado, 2002). It moves through the serotonin pathway, to the cell bodies in the Raphe nucleus and sends long axons to the neocortex, and the limbic system, and also descends the spinal cord to affect the motor neurons (NIDA, 2003).
MDMA's primary mechanism of action is by releasing 5-HT (serotonin)and blocking its reuptake (Palfai, Jankiewicz, 2001). It also increases the net release of norepinephrine, and dopamine, and blocks the reuptake of dopamine (Rivas-Vazquez, Delgado, 2002). MDMA stimulates serotonin efflux from plasma membrane vesicles and secretory vesicles (Rudnick, Wall, 1992). In the plasma membrane vesicles, MDMA inhibits serotonin transport by direct interaction with the sodium dependent transporter. MDMA inhibits ATP-dependent serotonin accumulation and stimulates efflux of previously accumulated serotonin (Rudnick, Wall, 1992). Usually after serotonin is released into the synaptic gap and is used, serotonin transporters move serotonin back into the presynaptic neuron to be metabolized. MDMA prevents the transporters from taking serotonin back into the presynaptic neuron. It can also cause the transporters to work in reverse bringing serotonin into the synaptic gap (NIDA, 2003).
http://www.humboldt.edu/~morgan/mdma_s03.htm


Posted by elena on Nov-25-2003 01:57:

chewing never lead to numbness for me, neither did sucking on them though that was just painfully disgusting. i dont think i noticed a dramatic difference in the "high" or the plateau of the "high" by the different intake methods either.
damnit, it's a pill ,it's just meant to be swallowed in the end.


Posted by TuanAnh213 on Nov-25-2003 02:04:

drugs drugs DRUGS DRUGS DRUGGGSSSSSSS!!!!!


Posted by UWM on Nov-25-2003 02:05:

I prefer insufflation or just eating the ******s by themselves. No chewing or sucking for me. Though crush/blow sure hurts like the devil.


Posted by Mike_B on Nov-25-2003 02:33:

quote:
Originally posted by DJ-Fuq
Its a bit more complicated than that.


you actually thought me a few things there, but most of that i knew, i oversimplified it just to prove the point that shoving mdma in your mouth or smashing in on your forehead isn't gonna make you high.

Also while were on the subject, maybe you have greater insight on what actually causes damage and how much mdma you can take at once or how long in between uses you should wait.

Based on what i could come up with, the damage is not cause by MDMA, but by your brain running out of serotonin, the ruptakes transporters of the serotonin neurons then start taking in Dopamine which has also been released into the cell. This would usually not occur because of an abundance of serotonin present in the synapse. Once inside the serotonin cells dopamine is broken down into two separated enzymes, one of which is actually toxic to the cell.

I figured, if you took a small amount of E, and 5-htp supplyments and only did it once and a while, like once every two months or so. You can minimize the damaged cause.

anyways, anymore thoughts on that?


Posted by DJ-Fuq on Nov-25-2003 03:15:

quote:
Originally posted by Mike_B
you actually thought me a few things there, but most of that i knew, i oversimplified it just to prove the point that shoving mdma in your mouth or smashing in on your forehead isn't gonna make you high.

Also while were on the subject, maybe you have greater insight on what actually causes damage


http://www.macalester.edu/~psych/wh.../dopamine2.html
That explains it pretty well.

quote:
and how much mdma you can take at once or how long in between uses you should wait.


I dont know I think the most anyone really knows is the less u take the safer u are.

quote:
Based on what i could come up with, the damage is not cause by MDMA, but by your brain running out of serotonin, the ruptakes transporters of the serotonin neurons then start taking in Dopamine which has also been released into the cell. This would usually not occur because of an abundance of serotonin present in the synapse. Once inside the serotonin cells dopamine is broken down into two separated enzymes, one of which is actually toxic to the cell.


"When dopamine is taken into the serotonin axons it will damage them. The axons are initially damaged by dopamine itself and then damaged by the byproduct that is produced when it is broken down by MAO (monoamine oxidase). Thus, the prevailing theory of the neurotoxic nature of MDMA is that dopamine is allowed to enter into the serotonin axons because of MDMA's inhibition of serotonin reuptake. The dopamine then works as a toxic element, ultimately destroying the serotonin neuron." (quote from the link)

quote:
I figured, if you took a small amount of E, and 5-htp supplyments and only did it once and a while, like once every two months or so. You can minimize the damaged cause.

anyways, anymore thoughts on that?


U might wanna read this:
http://www.erowid.org/chemicals/mdm..._article3.shtml


Posted by moncster on Nov-25-2003 03:15:

It's not like 5htp has no bad effects on the brain.


Posted by jdjd on Nov-25-2003 03:19:

just take g and you dont have to worry about all that
how long does it take for e to 'go bad'!?


Posted by Mike_B on Nov-25-2003 03:22:

5 htp doesn't harm you, its the main componant your body uses to create serotonin. Its found all over the place, Turkey had a high concentration of it.

as for http://www.erowid.org/chemicals/mdm..._article3.shtml

lol i used to read erowid all the time great source of info there.


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