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-- A Documentry recommendation thread
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I'm kind of tired so I haven't read the whole thread yet...don't know if this has been posted.
No Past to Speak of http://www.cbc.ca/documentaries/nopast.html
this is an incredible documentary. it's about infant rape in south africa. I know, sounds depressing, but the movie is done in incredible good taste and is ridiculously interesting. it is also one of the best documentaries I have seen in terms of style and form. it is pretty much exactly one hour long: it gets the message across, really makes you think, but is not to long. its the perfect length (granted I have a very short attention span, so I find a lot of documentaries tend to drag on). honestly the best made documentary I have ever seen.
cbc newsworld is playing great new documentaries every night at 10pm and 2am.
Links updated
Re: A Documentary recommendation thread
sorry accidental bump while editing
but on a side note, i find it sketchy that google video keeps changing the urls of videos. Censorship of the internet 
If Drugs Were Legal (Fictional Scenario)
^^^
lol
Re: ^^^
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| Originally posted by Jem_hadar lol |
If anyone has seen or knows of any tennis documentaries, I'd love to hear about them.
I'd be very interested in watching some on the sport or its great players!
Federer has really inspired me this Australian Open...
I'm DYING to see a fucking tennis documentary be made on him, one of the greatest players this game has ever seen!
Pett, whats the word... you ever come across or hear of any? 
Jem
Cool thread. I love documentaries. I just found out that my old high school buddy is the Managing Director of HotDocs. Next festival I will try and post some details here, and maybe try to score some passes for TAs...
A Life Without Pain
A LIFE WITHOUT PAIN - a documentary film directed by Melody Gilbert
http://www.alifewithoutpain.com/
Ever since Tuesday's episode of HOUSE, I have become beyond exceptionally interested in this topic.
It fascinates the hell out of me, and it not the blessing many might automatically think it is at first thought.
I cant even imagine. "Wow" is all I have to say with those that exist in this state. Its too bad what becomes of those who can't feel pain.
Unfortunate our bodies simply can't survive healthily w/o pain to curb our actions. We end up abusing ourselves without meaning to, and it one you just wouldnt think about.
This topic is so unreal.
Re: A Life Without Pain
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| Originally posted by Jem_hadar A LIFE WITHOUT PAIN - a documentary film directed by Melody Gilbert http://www.alifewithoutpain.com/ |
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World without pain is hell, parent says By A. Chris Gajilan CNN (CNN) -- When you first meet 4-year-old Roberto Salazar, you can't help but notice his unwavering smile and constant laughter. By all accounts, he's a very happy boy. It is only when he rams his head violently into walls or plays a little too roughly with a schoolmate, all the while smiling, that you are reminded that he suffers from an incredibly rare genetic disorder. Roberto is one of 17 people in the United States with "congenital insensitivity to pain with anhidrosis," referred to as CIPA by the few people who know about it. Roberto was born in July 2001, becoming Luis' and Juan's little brother. As a newborn, his parents thought he was the perfect baby. "Roberto was wonderful. He never cried. He would sleep 23 out of 24 hours a day. He never cried to eat, never cried that his diaper is itching," said his mother, Susan Stingley-Salazar. At 3 months, things abruptly changed. Roberto refused to eat. He was rapidly losing weight. His parents tried desperately to find ways to "force a child to eat that doesn't want to eat," Stingley-Salazar said. First they tried to feed him with an eyedropper. Then a feeding tube was attached to his stomach at 8 months. Other abnormalities quickly surfaced. Roberto was severely susceptible to heatstroke on hot summer days. His parents soon noticed he did not sweat. "You can't carry Roberto because he sucks your heat from your body. You're hot, sweaty. His body can't sweat like yours so he's just absorbing all of your heat," Stingley-Salazar said. His family was shocked when Roberto started teething. He gnawed on his own tongue, lips and fingers to the point of mutilation. "If you could imagine when you bite your tongue how bad it hurts. At one point, you couldn't even distinguish that his tongue was his tongue," Stingley-Salazar said. Stingley-Salazar, a registered nurse with a degree in molecular biology, took Roberto to see more than 60 physicians in the boy's first few years. She researched his symptoms on the Internet every night. She e-mailed any specialist she could find. She came up with very few answers until she contacted Dr. Felicia Axelrod of the New York University Dysautonomia Treatment and Evaluation Center. Axelrod has studied this family of "no-pain" diseases for more than 35 years. These genetic disorders affect the autonomic nervous system -- which controls blood pressure, heart rate, sweating, the sensory nerve system and the ability to feel pain and temperature. Stingley-Salazar's first reaction: "There is somebody out there who actually knows what we've been going through, you know, the hell we've been living for the last two-and-a-half years." CIPA is the most severe and fatal type of the seven types of hereditary sensory and autonomic neuropathy, or HSAN. Overheating kills more than half of all children with CIPA before age 3, Stingley-Salazar said. According to Axelrod, levels of pain vary. "For some children it's a mild degree such as breaking a leg, they'll get up and walk on the leg. They feel that something is uncomfortable but they keep on moving," she said. "For other children, the pain loss is so severe that they can injure themselves repetitively and actually mutilate themselves because they don't know when to stop." All HSAN disorders are recessive genetic disorders -- both parents have to carry the genetic mutation in order to pass it on to a child. But there is less than a 1-in-4 chance that the child will develop it. Neither of Roberto's older brothers has the disorder. A more common HSAN condition is familial dysautonomia, or FD. There are about 500 cases of FD in the United States, Axelrod said. The first sign of FD is a child's inability to suck properly followed by delayed milestones -- these children walk and speak later. Often, FD patients endure severely dry eyes because they are unable to produce tears. Also, part of this sensory disorder is difficulty "telling where they are in space," Axelrod said. The minor effect is constantly bumping into things. The major effect is that 80 percent of these kids suffer curvature of the spine because they have no concept of posture. "The hardest thing growing up with FD is that sometimes your balance can be off. Also when you get busy, like when your blood pressure drops, I faint. It's scary for people who don't know what to do," 15-year-old Perry Goldberger said. Perry was diagnosed when she was 2 weeks old. She, too, suffers from common ailments of HSAN -- she gets liquids through a stomach tube; she can't distinguish between hot and cold; she doesn't feel pain. Perry has learned to handle her daily medical regimen: During the day she takes nebulizer treatments for her lungs and seven tube feedings. At night she must use an oxygen machine to help her breathe and must place a moisture chamber around her eyes while she sleeps. "This is my daily schedule that I take every single day. You get used to it after a while," she said. Her mother, Laurie Goldberger, said her family takes it one day at a time and is teaching Perry a certain level of independence. "Now at 15, she's gotten very responsible and understands it and she knows she has to take it. So at school she does her own medicine," Goldberger said. Axelrod points to Perry as an example of the huge strides made in HSAN disorders. "Forty years ago, a child with FD had a 50 percent probability of reaching the age of 5," she said. "Today, a child born with FD would have a 50 percent probability of reaching the age of 40." |
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Girl with rare disease doesn't know pain picture of Ashlyn Blocker Ashlyn Blocker, 5, must be checked for scrapes and cuts because she cannot feel pain. PATTERSON, Georgia (AP) -- Ashlyn Blocker's parents and kindergarten teachers all describe her the same way: fearless. So they nervously watch her plunge full-tilt into a childhood deprived of natural alarms. In the school cafeteria, teachers put ice in 5-year-old Ashlyn's chili. If her lunch is scalding hot, she'll gulp it down anyway. On the playground, a teacher's aide watches Ashlyn from within 15 feet, keeping her off the jungle gym and giving chase when she runs. If she takes a hard fall, Ashlyn won't cry. Ashlyn is among a tiny number of people in the world known to have congenital insensitivity to pain with anhidrosis, or CIPA -- a rare genetic disorder that makes her unable to feel pain. "Some people would say that's a good thing. But no, it's not," says Tara Blocker, Ashlyn's mother. "Pain's there for a reason. It lets your body know something's wrong and it needs to be fixed. I'd give anything for her to feel pain." The untreatable disease also makes Ashlyn incapable of sensing extreme temperatures -- hot or cold -- disabling her body's ability to cool itself by sweating. Otherwise, her senses are normal. Ashlyn can feel the texture of nickels and dimes she sorts into piles on her bedroom floor, the heft of the pink backpack she totes to school and the embrace of a hug. She feels hunger cravings for her favorite after-school snack, pickles and strawberry milk. That's because the genetic mutation that causes CIPA only disrupts the development of the small nerve fibers that carry sensations of pain, heat and cold to the brain. "There are all kinds of different nerve cells that help us feel different sensations," says Dr. Felicia Axelrod, a professor of pediatrics and neurology at New York University School of Medicine. "You can have one sense removed, just like you can lose your hearing but still smell things." Number afflicted unknown Specialists such as Axelrod don't know how many people suffer from CIPA. As director of a treatment center that specializes in CIPA and related disorders, Axelrod has 35 patients with the disease on file. Only 17 of them are from the United States. Japan has the world's only association for CIPA patients. It has 67 members. In Patterson, a rural town of 800 people in southeast Georgia, John and Tara Blocker had no idea the disorder existed before they took Ashlyn to the doctor for a bloodshot, swollen left eye when she was 8 months old. The doctor put drops in Ashlyn's eye to stain any particles that might be irritating it. The infant smiled and bounced in her mother's lap while the dye revealed a massive scratch across her cornea. "They put the dye in her eye and I remember the look of puzzlement on all their faces," Ashlyn's mother says. "She was not phased by it by any means." Tests by a geneticist led to Ashlyn's diagnosis. To have the disorder, Ashlyn had to inherit two copies of the mutated gene -- one from each parent. Ashlyn's father, a telephone technician, and mother, who holds a degree in physical education, were largely on their own in learning to cope with their daughter's strange indifference to injury. Many things they couldn't anticipate. Ashlyn's baby teeth posed big problems. She would chew her lips bloody in her sleep, bite through her tongue while eating, and once even stuck a finger in her mouth and stripped flesh from it. Family photos reveal a series of these self-inflicted injuries. One picture shows Ashlyn in her Christmas dress, hair neatly coifed, with a swollen lip, missing teeth, puffy eye and athletic tape wrapped around her hands to protect them. She smiles like a little boxer who won a prize bout. Her first serious injury came at age 3, when she laid her hand on a hot pressure washer in the back yard. Ashlyn's mother found her staring at her red, blistered palm. "That was a real reality check for me. At that point I realized we're not going to be able to stop all the bad stuff," Tara Blocker says. "She needs a normal life, with limitations." So when Ashlyn goes to her kindergarten class at Patterson Elementary School, she gets daily check-ups with school nurse Beth Cloud after recess. Cloud and Ashlyn's mother discussed having her wear a helmet on the playground, but decided it would look too odd. And when teacher's aide Sue Price puts ice in Ashlyn's chili at lunch, her dozen classmates get ice in theirs too. Infections with no outward symptoms also concern them. They heard of a case where a child with CIPA had appendicitis that went untreated until her appendix burst. "It's a lot to take in. It opens your eyes to things you wouldn't normally think about," says Tara Blocker. "If she sees blood, she knows to stop. There's only so much you can tell a 5-year-old." |
I saw that one jamie. Here is another that moved me, and made me cry and cringe and smile all at the same time, a unbeleiveable watch.
http://www.cbc.ca/passionateeyemond...ure_111004.html
The Boy Whose Skin Fell Off (2004)
In September 2003 36-year-old Jonny Kennedy died. He had a terrible genetic condition called Dystrophic Epidermolysis Bullosa (EB) - which meant that his skin literally fell off at the slightest touch, leaving his body covered in agonising sores and leading to a final fight against skin cancer.
In his last months Jonny decided to work with filmmaker Patrick Collerton to document his life and death, and the result was a film, first broadcast in March, that was an uplifting, confounding and provocatively humorous story of a singular man. Not shying away from the grim reality of EB, the film was also a celebration of a life lived to the full.
Produced and directed by Patrick Collerton and first shown in March 2004 The Boy Whose Skin Fell Off has become the most talked about documentary of that year
It attracted nearly five million viewers and after the screening the public donated over half a million pounds to Jonny�s charity, DEBRA. A Jonny Kennedy Memorial Fund has been set up to raise another half a million with the aim of ensuring that Jonny Kennedy left a one million pound legacy.
It has also been nominated, and subsequently won many national and international awards notably the International Emmy for Documentary in 2004.
source:
http://www.yippfilms.com/documentary/the_boy/
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| Originally posted by MKpacha I saw that one jamie. Here is another that moved me, and made me cry and cringe and smile all at the same time, a unbeleiveable watch. http://www.cbc.ca/passionateeyemond...ure_111004.html The Boy Whose Skin Fell Off (2004) In September 2003 36-year-old Jonny Kennedy died. He had a terrible genetic condition called Dystrophic Epidermolysis Bullosa (EB) - which meant that his skin literally fell off at the slightest touch, leaving his body covered in agonising sores and leading to a final fight against skin cancer. In his last months Jonny decided to work with filmmaker Patrick Collerton to document his life and death, and the result was a film, first broadcast in March, that was an uplifting, confounding and provocatively humorous story of a singular man. Not shying away from the grim reality of EB, the film was also a celebration of a life lived to the full. Produced and directed by Patrick Collerton and first shown in March 2004 The Boy Whose Skin Fell Off has become the most talked about documentary of that year It attracted nearly five million viewers and after the screening the public donated over half a million pounds to Jonny�s charity, DEBRA. A Jonny Kennedy Memorial Fund has been set up to raise another half a million with the aim of ensuring that Jonny Kennedy left a one million pound legacy. It has also been nominated, and subsequently won many national and international awards notably the International Emmy for Documentary in 2004. source: http://www.yippfilms.com/documentary/the_boy/ |
Re: Re: A Life Without Pain
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| Originally posted by Jem_hadar Relates stories about the above, to give you all an idea. |
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American girl feels no pain and smiles to her own blood 12/15/2004 16:46 Those people, who do not feel any pain at all, usually die before they turn 25 When the girl was 12 months, she could easily bite her own finger off and feel no pain at all. When she was three years old, she put her hand on a red-hot oven, and burnt her skin. Parents were shocked, when they saw blood all over the kitchen, while their daughter was sitting there smiling. The girl can also bite her tongue through when she eats. "This is not a gift from heaven, this is a curse!" the girl's mother exclaims. Five-year-old Ashlyn Blocker from the town of Patterson, Georgia, is sitting on the ground playing with her doll, while two cameras are filming her. Ashlyn suffers from one of the rarest diseases in the world. Adolf Hitler was highly interested in the phenomenon: he ordered to explore it in 1944 to create an army of fearless supersoldiers. When little Ashlyn falls down and scratches her keens, she does not cry or scream with pain. A child, who never cries, may seem to be a dream for every parent. Ashlyn's parents, however, are not happy at all. Thirty-five US citizens suffer from CIPA - an ultra rare disease, which deprives an individual of such an important natural protection as pain. There are a hundred people like that living on the whole planet. CIPA is a highly extraordinary genetic disorder. Scientists believe that the disorder may occur when parents have different blood groups. It may occur, although it does not happen with the majority of people. A lot of parents would be happy to have a baby, who does not wake them up at night. Ashlyn's mother was also happy to realize that her daughter was such a quiet little baby. However, the girl's peaceful behavior raised suspicion with the woman and she decided to take her baby to the hospital. A research did not reveal anything strange, although doctors did not take a blood sample for the genetic analysis. When Ashlyn's teeth started growing at the age of six months, the girl shredded her own lips with them. Doctors examined the girl in a special clinic and found out the reason of her unusual behavior. It turned out that Ashlyn's genes, which were responsible for pain impulses, were damaged. The little girl's senses are fine, although she does not show any sensitivity to any kind of pain. In addition, the girl's body does not produce sweat, which is very dangerous too - the child can die in very hot weather. Modern science does not have a remedy to cure the disease - that is why Ashlyn's parents and relatives constantly fear for the baby's life. The fear of the girl's parents is easy to understand: those, who do not feel any pain at all, usually die before they turn 25 years old. As a rule, painless individuals die of appendicitis: they do not feel pain in the right side, and notice the problem too late, when the deadly inflammation starts. Such people die of frostbites, heat strokes, blood poisoning, which can be caused with a slight wound; they do not feel any pain even when they have a heart attack. Ashlyn's parents say that they are trying to make her think that blood is bad, that she needs to ask for help every time, when she sees her own blood. Doctors do not know, what will happen to the girl when she grows and gives birth to her own child, because she will not be able to feel contractions. The parents have to be highly careful even when they feed Ashlyn: "We can't leave her alone when she eats. We can't give her hot meals - she can burn her mouth with them. She can also bite her tongue through," they say. Ashlyn Blocker will have to live a very difficult and hazardous life. It may sound like a paradox, but the feeling of pain has become an unfeasible dream for the girl and her parents. It is worth mentioning that unique, inexplicable phenomena are more common with children rather than adults. There is a ten-year-old boy in China, whose bodily temperature is 43 degrees. The boy is quite healthy; he has never had flu, although any other normal person would die in his place. Another superchild was born in the former Soviet republic of Georgia. The boy is only 15 months old, but he has already made a Guinness Book record with his weight of 26 kilograms. A five-year-old Hamburg resident is as strong as a 15-year-old kid. Another child prodigy lives in Iraq - the boy has not been able to sleep for more than two years. Scientists have never been able to find any explanation to such mysterious phenomena. http://www.unexplainable.net/artman...icle_1274.shtml |
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The one-in-a-billion boy who feels no pain Last updated at 10:00am on 21st January 2005 Ben Whittaker: The toddler pulled out one of his teeth without even blinking When Ben Whittaker picked up a piping hot chip from his father's plate one day, he blistered three of his fingers - but showed no sign of distress. The baby's parents were amazed. And they were astounded when he pulled out one of his teeth without even blinking. Joanne and Wayne Whittaker sensed that their son was no ordinary boy. Indeed, they soon learned that he is one in a billion. As a result of a rare genetic disorder, Ben is totally immune to pain. Only the 33rd person to ever be diagnosed with the condition, the boisterous 17-month-old never sheds a tear however badly he hurts himself. When he fractured his heel while playing at home he didn't cry at all. His parents took him to hospital, but Ben simply ran off without a care in the world once the doctors put his ankle in plaster. Danger Although Ben feels no pain, his condition does pose some serious dangers. Specialists at Sheffield Children's Hospital are worried that he could bite off the end of his tongue without knowing it and have suggested removing all his baby teeth to save him from hurting himself. His mother, 33, says she dare not let Ben out of her sight for a moment. Speaking at the family home in Royston, South Yorkshire, she said: "At first we just thought he was an extra tough little cookie, but gradually we began to realise he was just too tough to be true. "It might sound appealing having no sense of pain, but the condition means we have to be on our guard every minute of every day. I'm always terrified he's going to put his hand in the fire or burn himself on a radiator. "If he falls or bangs his head he never makes a peep. Nothing seems to hurt him. Ben's so immune that he bit right through his tongue and didn't feel a thing. He was nine months old when he blistered his fingers with the chip. It was a nasty burn, but he didn't react at all. "His fractured heel made no impression on him. Once they put the plaster on his ankle he was running round the accident and emergency department as though nothing had happened at all." Little doctors can do His father, who works as a joiner, says there is little that doctors can do to treat the little-known condition. "The health visitor was the first person to realise something was wrong," he said. "Ben underwent a lot of tests at the children's hospital, and when they sent tiny electrical impulses through his nervous system they found his brain wasn't interpreting the pain signals properly." The disorder, known as congenital indifference to pain, was first diagnosed in the 1930s. Only 32 other cases have been identified before. Experts believe the condition is caused by the failure of a substance called betaendorphin that occurs naturally in the body and modulates pain sensations. The Whittakers are hoping to contact families of other victims to get more advice on the condition. "In the meantime we've just got to be extra vigilant and watch Ben every minute of every day," said Mrs Whittaker. |
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CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS Congenital Insensitivity to Pain with Anhidrosis (lack of sweating) is a rare autosomal-recessive disorder usually manifested in childhood by a history of unrecognized trauma, indifference to pain stimuli or self-mutilation. This disorder is a rare sensory and autonomic neuropathy which is defined as the absence of normal subjective and objective responses to noxious stimuli in patients shown to have normal central and peripheral nervous systems. Clinical appearance of patients with congenital insensitivity to pain. INTRODUCTION HOW IS THE BRAIN INVOLVED? NOCICEPTION PATHWAY MAIN FEATURES OF DISORDER CASE STUDIES REFERENCES INTRODUCTION -------------------------------------------------------------------------------- Patients diagnosed with congenital insensitivity to pain with anhidrosis (CIPA) suffer from abnormal pain and temperature perception, absence of sweating (anhidrosis), mental retardation, fever during hot weather and loss of unmyelinated fibers with a decrease in size of small myelinated fibers. Body temperature is disturbed as a result of the inability to sweat and insensitivity to pain may lead to bone fracture, multiple scars, osteomyelitis, and joint deformities, which may lead to limb amputation, painless injuries of arms, legs and oral structures. This disorder results from a defect in neural crest differentiation and the system responsible for pain and temperature sensation, the first-order afferent system, is lost. Nociceptive neurons in the dorsal root ganglia derive from the neural crest and they can only survive if they are stimulated by the nerve growth factor (NGF) through the TrkA receptor. Mutations in the TrkA gene have shown a correlation with the defective development of the nociceptive neurons. HOW IS THE BRAIN INVOLVED? -------------------------------------------------------------------------------- NGF AND TrkA GENE The survival of neurons during development is largely dependent on neurotrophic factors, the most important being the NGF family. These neurotrophins recognize two different classes of receptors, the TrK family of tyrosine-protein kinases and the low-affinity receptor, p75. Three types of TrK receptors,such as TrkA, TrkB, and TrkC have been found. TrkA is the receptor that signals NGF, TrkB signals brain-derived neurotrophic factors and neurotrophin-4, and TrkC is the primary receptor for neurotrophin-3. The P75 receptor facilitates the interaction between the signaling receptor TrkA and NGF by increasing the concentration of NGF in the general area of the TrkA receptors. NGF is produced by target cells consisting of gland, muscle or skin cells. NGF stimulates the survival of cells, derived from the neural crest. These cells include nociceptive neurons and cells p75 receptor of the sypmathetic ganglia. The receptors, TrkA, mediate the effects of NGF and are mainly found on cells derived by the neural crest in the nervous system. Abnormalities found in patients that carry a disruption in NGF, p75, or TrkA genes are similar to the pathological finding in CIPA. NOCICEPTION PATHWAY -------------------------------------------------------------------------------- This the pathway that pain takes through the brain: lumbar spinal cord, cervical spinal cord, lower medulla, mid-medulla, mid pons, midbrain, ventral posterior lateral nucleus thalamus, primary somatosensory cortex and cerebrum. MAIN FEATURES OF THE DISORDER -------------------------------------------------------------------------------- The main features of the disorder are: lack of pain sensation, painless injuries of the arms, legs and oral structures, fever during hot weather because of inablilty to sweat (anhidrosis), mental retardation, infection and scaring of the tongue, lips and gums, chronic infections of bones and joints, bone fractures, multiple scars, osteomyelitis and joint deformities, which may lead to amputation. CASE STUDIES -------------------------------------------------------------------------------- People with congenital insensitivity to pain go through life in danger of destroying their bodies because they do not realize the harm they are doing. Many die young and for those who don't they go through life experiencing a different sort of pain. Take into consideration a 13-month-old Pakistani boy who was referred to an orthodontist by his physician after experiencing repeated tongue bitting resulting in ulceration and loss of the tip of his tongue. He had recently been diagnosed as having CIPA which means that he could feel pressure and touch but didn't react to noxious stimuli. He showed little or no response to circumcision performed without anesthesia. At six months he developed osteomyelitis and soon after, severly burnt his finger tips by holding a radiator. At this same time he began to bite his tongue. Severe burns on finger tips from holding a radiator and extensive lacerations of tongue with loss of the tip. The orthodontist suggested that they try to maintain the teeth to protect the tissues from futher damage. A mouthguard was constructed and fitted to protect the tongue. However, it was noted that the patient began experiencing sores in his mouth from the mouthguard. Three more mouthguard were introduced to minimize trauma by rotating the guards. This treatment resulted in much resolution of the ulcerations and helped reduce the chewing. The most well documented case of CIPA was Ms. C. She was a young Canadian student who attended school at McGill University in Montreal. Her father was a physician and was aware of her condition. He asked his colleagues in Montreal to examine his daughter. They concluded that Ms. C was normal in every way except that she felt no pain. She had bitten off the tip of her tongue as a child while chewing food and had suffered third-degree burns after keneeling on a hot radiator. When examined by the psychologist, Ms.C reported that she felt no pain when noxious stimuli were presented. Even when parts of her body were subjected to electirc shock, hot water at burning temperatures or a long ice bath she reportedly felt no pain. It was noted that she showed no changes in blood pressure, heart rate, or respiration when exposed to these conditions. Ms. C claimed that she could not remember sneezing or coughing and could only stimulate her gag reflex with much difficulty. The doctors at Montreal put Ms.C through a series of tests such as: inserting a stick up through the nostrils, pinching tendons, or injecting histamines under the skin. All of these tests failed to produce pain. Ms. C had severe medical problems. She exhibited pathological changes in her knees, hips and spine and underwent several operations to fix these problems. Her doctors explained these changes as a lack of protection to her joints usually given by the sensation of pain. She could not shift her weight when standing, turn over in her sleep, or avoid certain postures. In an individual without CIPA, these things prevent inflammation of the joints. Ms. C died at the age of 29 of massive infections that could not be brought under control. During her last month she reportedly complained of discomfort, tenderness and pain. This was unexplained by her physicians. REFERENCES -------------------------------------------------------------------------------- Okuda, K., Toshimi, A., Miwa, T., & Hiroki, K., (2000). Anaesthetic management of children with congenital insensitivity to pain with anhidrosis. Pediatric Anaesthesia, 10, 545-548. Indo, Y., & Hayashida, Y., (1996). Mutations in the TrkA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. Nature Genet, 13, 485-488. Littlewood, S. J., & Mitchell, L., (1998). The dental problems and management of a patient suffering from congenital insensitivity to pain. International Journal of Pediatric Dentistry, 8, 47-50. Yotsumoto, S., Setoyama, M., Hozumi, H., Mozoguchi, S., Fukumaru, S., Kobayashi, K., Saheki, T., & Kanzaki, T., (1999). A novel point mutation affecting the tyrosine kinase domain of the TrkA gene. The Society for Investigative Dermatology, 112, 810-814. |
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Congenital Insensitivity to Pain with Anhidrosis Sarah Sniezek Congenital Insensitivity to Pain with Anhidrosis (CIPA) is a rare disease which causes one to lose their feeling of pain. I read this article a couple of weeks ago about a girl who has this rare disease and is incapable of feeling pain and will never know what pain is. It intrigued me and sparked my web paper topic. I wanted to know everything there is to know about this disease and my research to give me answers, but, of course, this was not the case. The more and more I researched I began to wonder if this supports our notion of the "Brain =Behavior". There is so much more to learn about this fairly young disease and with that please take into account that these are sources off the internet and one could not know if they are fully accurate or not. As for the deep detail of the topic, such as names of different genes and etc, I do not fully understand their full meaning so I will write about what I took from all the different information about CIPA. CIPA is a disease that is very new and that very few people have. There are only thirty-five US Citizens that have CIPA, and most people with this disease usually do not live past 25, which makes it very difficult to study and to come closer to "getting it less wrong". ((1)) This one particular girl, Ashlyn Blocker, has CIPA which causes her life to be very difficult. Since the young girl was born with CPI, she would have no idea what pain feels like and cannot relate to most people. Most of us, from the day we are born, have this intuitive notion about pain. We feel it and know to be aware of it from learning from our experiences. Imagine being unable to learn what pain is because you are unable to have similar experiences. Well, that is how this young girl was born. Most people would think it would be great to live without pain, but pain is an indication to our brain that our body needs something. Ashlyn is incapable of living a normal life and has to be examined regularly because there is no way to know if she is endanger of killing herself through high fevers because of the inability to sweat, unknown injuries, and etc. ((4)) Ashlyn's case is rare within the world, but there are other studies of people from different ethnic background which also get CIPA. Through these few studies there has been extensive research done and there are many correlations found. So far, CIPA is defined as an autosomal-recessive disorder ((2)) which is a developmental defect (not necessarily hereditary) ((3)) that usually is caused by a history of some kind of trauma. The person affected by this is unable to feel pain, even though they seem to show a normal central and peripheral nervous system. ((3)) With is young disease there are many questions and hypotheses brought up. There are many correlations and observations. On one study of CIPA, many different people having CIPA were observed and Clinical features, Pathological findings, and Molecular Genetics were all taken into account. Under the Clinical features one finding showed that in CIPA patients there is an overproduction of brain endorphins which could be some how interrelated to this disorder. ((3)) Another study was done by taking a biopsy of the cutaneous branch of the radial nerve of two patients with CIPA, differing in gender and age. Within the older of the two patient's biopsy of the radial nerve, there showed to be no small myelinated and unmyelinated fibers but within the younger of the patient the biopsy showed that they were lacking unmyelinated fibers and that the amount of small myelinated fibers was decreased. This suggests "that the disorder was not a hereditary sensory neuropathy, but rather a developmental defect" ((3)). Another pathological finding was that patients with a very small amount of nerve fibers were more likely to have rare nerve fibers in the dermis and no nerve branches or endings on the epidermis. These patients are classified as HSAN4 patients. The studied concluded that these patients "have a hereditary developmental defect of nerve outgrowth"((3)). Lastly, the study of Molecular Genetics within CIPA patients gives the most substantial information. The study of a gene tyrosine kinase (NTRK1) which is related to the nerve growth factor (NGF) within the patients having CIPA seemed to be the mutation causing CIPA. This study also suggests that there are other TRK and neurotrophin genes might be the cause of developmental defects of the nervous system. ((3)) As for these studies, they just bring me closer to understanding what I want to understand between the brain and its behaviors. So far within this semester I have been trying to find something to show me that the brain and behavior are not equal, but I still cannot find anything. This rare disease, CIPA, shows that the brain and behavior are equal. People affected by this disease feel no pain and will never understand what pain is. Their behavior is equivalent with their brain state. I find it interesting though that these people affected by CIPA act the function normally other than them not being able to feel pain and sweat. I wonder is there also something different within their brain. One study did show that there was an increase of endorphins within patients' brains that have CIPA, what does that show? Does it change anything? Why is their behavior still the same as most people other than the feeling of no pain? Is the only difference within their brain their insensitivity to pain? I went into this research wondering about this disease and if it actually went against "brain=behavior" and it has not so far. It only makes the argument less wrong. This disease affects ones nerves because of a mutation of some sort, most likely a gene mutation within the NTRK1. The behavior still reflects ones brain state. http://serendip.brynmawr.edu/bb/neuro/neuro05/web1/ssniezek.html |
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| Originally posted by Surreal JRS An Inconvenient Truth (Al Gore). Part 1 of 2 Part 2 of 2 |
Pump Up The Volume: The Rise Of House Music
Part 1
Part 2
Part 3
Here's some history for you n00bies 
my penis and I (2005)
about a british dude going on a quest to determine whether a small penis matters.
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| Originally posted by jchung52 my penis and I (2005) about a british dude going on a quest to determine whether a small penis matters. |
Stanford Prison Experiment - Psychology of Imprisonment
The Stanford prison experiment was a psychological study of the human response to captivity, in particular, to the real world circumstances of prison life and the effects of imposed social roles on behavior. It was conducted in 1971 by a team of researchers led by Philip Zimbardo of Stanford University. Undergraduate volunteers played the roles of guards and prisoners living in a mock prison built in the basement of the Stanford psychology building. Prisoners and guards rapidly adapted to their assigned roles, stepping beyond the boundaries of what had been predicted and leading to genuinely dangerous and psychologically damaging situations. One-third of guards were judged to have exhibited "genuine" sadistic tendencies, while many prisoners were emotionally traumatized and two had to be removed from the experiment early. Despite the now highly unsanitary and out of control conditions evident, only one of 50 observers, graduate interviewer Christina Maslach, objected to the experiment. Zimbardo then ended the experiment early.
Ethical concerns surrounding the famous experiment often draw comparisons to the Milgram experiment, which was conducted in 1963 at Yale University by Stanley Milgram, Zimbardo's former high school friend.
Must Watch
VIDEO LINK
50minutes
[[ LINK REMOVED ]]
Daniel T. is a "super brain." He can calculate numbers to hundreds of decimal points in seconds and learn new languages in a week. Through a series of real world challenges and complex number problems, Daniel's amazing abilities are demonstrated.
Dont know if this was posted yet or not but Bus 147....can rent it at blockbuster...A documentary featuring real footage of a man who took a commuter bus hostage in Brazil....shows you what made him get to the point of hijacking a bus, basically showing you how street kids are treated in the slums of brazil....soo coool
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| Originally posted by infinity HiGH Pump Up The Volume: The Rise Of House Music Part 1 Part 2 Part 3 Here's some history for you n00bies |
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| Originally posted by geroin Stanford Prison Experiment - Psychology of Imprisonment The Stanford prison experiment was a psychological study of the human response to captivity, in particular, to the real world circumstances of prison life and the effects of imposed social roles on behavior. It was conducted in 1971 by a team of researchers led by Philip Zimbardo of Stanford University. Undergraduate volunteers played the roles of guards and prisoners living in a mock prison built in the basement of the Stanford psychology building. Prisoners and guards rapidly adapted to their assigned roles, stepping beyond the boundaries of what had been predicted and leading to genuinely dangerous and psychologically damaging situations. One-third of guards were judged to have exhibited "genuine" sadistic tendencies, while many prisoners were emotionally traumatized and two had to be removed from the experiment early. Despite the now highly unsanitary and out of control conditions evident, only one of 50 observers, graduate interviewer Christina Maslach, objected to the experiment. Zimbardo then ended the experiment early. Ethical concerns surrounding the famous experiment often draw comparisons to the Milgram experiment, which was conducted in 1963 at Yale University by Stanley Milgram, Zimbardo's former high school friend. Must Watch VIDEO LINK 50minutes |
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| Originally posted by infinity HiGH Pump Up The Volume: The Rise Of House Music Part 1 Part 2 Part 3 Here's some history for you n00bies |
| quote: |
| Originally posted by Oreo_The_Cookie [[ LINK REMOVED ]] Daniel T. is a "super brain." He can calculate numbers to hundreds of decimal points in seconds and learn new languages in a week. Through a series of real world challenges and complex number problems, Daniel's amazing abilities are demonstrated. |
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| Originally posted by Jem_hadar COOL! (hehe, kinda like lisa from newsradio ) |
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