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-- Amphetamines may slow Parkinson's, study shows
Amphetamines may slow Parkinson's, study shows
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| Amphetamines may slow Parkinson's, study shows Thu Aug 4, 9:31 AM ET REUTERS Amphetamines, including the party drug Ecstasy, have reversed the effects of Parkinson's disease in mice, researchers said on Wednesday. Their finding does not suggest the use of now-illegal drugs to treat the incurable brain disease, but may offer a way forward in helping patients, they said. The team at Duke University in North Carolina treated mice that were genetically modified to suffer from Parkinson's-like symptoms with more than 60 types of amphetamines. Fourteen of the drugs helped reverse the symptoms of the mice, including the tremors and rigidity that mark the disease -- raising the possibility of exploring related treatments for humans. "We hope to find new drugs that are close chemically, but safe," Marc Caron, who led the research, said in a telephone interview. Parkinson's disease is caused by the death of brain cells that control physical movement and produce the essential chemical dopamine. According to the American Parkinson's Disease Association, there are about 1.5 million Americans with the disease. The new research shows that dopamine replacement, so far the most common, but only partly effective Parkinson's treatment, may not be the only viable option, Caron said. Amphetamine-like drugs, not unlike those now given to children with attention deficit disorder, could eventually be used for Parkinson's, he said. "We give these drugs in low doses to children, so it's not so terrible to say some day we should give similar drugs to Parkinson's patients," Caron said. The effects of another stimulant, coffee, have been cited in the past as easing Parkinson's symptoms by keeping dopamine levels high. But Caron said coffee is only effective in early stages of the disease, when some dopamine is still present. His new study reflects treatment during advanced stages, when there is no longer any dopamine present. MDMA, also known as Ecstasy, proved the most effective of the amphetamines used at counteracting Parkinson's symptoms in the mice, said Raul Gainetdinov, who also worked on the study. He said he is not sure exactly why. "We do not advocate self-medication with Ecstasy," Gainetdinov added in a telephone interview. He said that apart from being illegal and controversial, the drug can be more damaging to human nerve tissue than it is to mice. Caron and Gainetdinov's findings were published in the August edition of Public Library of Science Biology. |
GREAT! Now Michael J. Fox and I can finally finish that game of Jenga we have had on hold for the past few years!
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| Originally posted by VERTiG0 GREAT! Now me and Michael J. Fox can finally finish that game of Jenga we have had on hold for the past few years! |
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| Originally posted by VERTiG0 GREAT! Now Michael J. Fox and I can finally finish that game of Jenga we have had on hold for the past few years! |
I was reading a while back that many dopaminergic substances in varying degrees can help protect against Parkinson's and Alzheimer's... ie cocaine, methamphetamine, nicotine, alcohol, Bupropion (Wellbutrin, Zyban), Ritalin, caffeine, etc...
I guess the theory is if you keep the specific dopamine neurons stimulated, they won't shrivel away and die. Kind of a use it or lose it type of deal I guess? 
Then again, the longterm abuse of said substances can also cause types of neuronal death too...
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| Originally posted by SurrJRS I was reading a while back that many dopaminergic substances in varying degrees can help protect against Parkinson's and Alzheimer's... ie cocaine, methamphetamine, nicotine, alcohol, Bupropion (Wellbutrin, Zyban), Ritalin, etc... I guess the theory is if you keep the specific dopamine neurons stimulated, they won't shrivel away and die. Kind of a use it or lose it type of deal I guess? Then again, the longterm abuse of said substances can also cause types of neuronal death too... |
I guess drug dealers can put "Healthcare Practitioner" on their business cards now 
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| Originally posted by MarkT I guess drug dealers can put "Healthcare Practitioner" on their business cards now |
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| Originally posted by Moral Hazard let's see.... substances I use(ed)... cocaine, check methanphetamine, check nicotine, check alcohol, check Bupropion (Zyban), check Ritalin, no 5/6.... I should live forever! |
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| Originally posted by SurrJRS Hah not quite. The key is to come up with highly targeted pharmaceuticals, because most of what we have today also greatly affects other areas of the body as well (hence a lot of nasty side effects). I'm thinking for Parkinson's, a combination of nanotechnology and stem cells would be a good. |
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| Originally posted by Moral Hazard only if they have a self-regulating college! |
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| Originally posted by Moral Hazard BETTER LIVING THROUGH CHEMISTRY!!!! |
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| Originally posted by Moral Hazard BETTER LIVING THROUGH CHEMISTRY! |
I recently learned that in 2002 a researcher from the University of Toronto had done a study that proved "e" helped those with Parkinson's Disease. University of New York confirmed the same results...but at the request of Bush Admin...a seperate research was done by the DEA and it was found not to help at all and John Hopkin's was Contracted by DEA to put it into publication because The Bush Admin did not want this resent discovery to justify it's use for medicinal purposes as does the Marijuana factor.
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| Originally posted by VERTiG0 GREAT! Now Michael J. Fox and I can finally finish that game of Jenga we have had on hold for the past few years! |
I've posted this before, but MAPS (Multidisciplinary Association for Psychedelic Studies) has embarked on a $5 million, 5-year Clinical Plan to make MDMA into a prescription medicine for the treatment of post-traumatic stress disorder. (Maybe Parkinson's to follow?)
http://www.maps.org/research/mdma/
^^^ imagine the line-ups at doctor's offices if that ever happens.
"I have post-traumatic stress disorder...give me e!" LOL
^^^^They are already giving E to American soldiers!
Thursday February 17, 2005 - The Guardian.
Ecstasy trials for combat stress
American soldiers traumatised by fighting in Iraq and Afghanistan are to be offered the drug ecstasy to help free them of flashbacks and recurring nightmares.
Read full article:
http://www.guardian.co.uk/internati...1416055,00.html
Yeah and your heart too!
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