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Try building up a small library of lead sounds on a single synth. Then you can loop the melody, and flick through each sound on the synth seeing what it sounds like. Don't forget to try adding some delay (etc.) when doing this 
Also, why not try some totally different sounds? Much of the time it won't sound good enough, but there are times when an unconventional sound makes an interesting lead, and will really make your track stand out!
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