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Assuming you've already got the MIDI part working, all you need to do is connect the audio out of your synth to the audio in of the 1820 or breakout box. As far as PatchMix is considered, the default templates *should* already have strips set up for each audio in, but if not, then just append a new strip and select the correct physical source from the drop-down, give it a descriptive title (optional), then open up the VST Connections in Nuendo and create a bus mapped to that ASIO strip.
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