"Part of the physiological process of erection involves the parasympathetic nervous system causing the release of nitric oxide (NO) in the corpus cavernosum of the penis. NO binds to the receptors of the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation (vasodilation) in the corpus cavernosum, resulting in increased inflow of blood and an erection.
Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections. Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil should not cause an erection. Other drugs that operate by the same mechanism include tadalafil (Cialis®) and vardenafil (Levitra®).
Sildenafil is metabolised by hepatic enzymes and excreted by both the liver and kidneys. If taken with a high fat meal, there may be a delay in absorption of sildenafil and the peak effect might be reduced slightly as the plasma concentration will be lowered."
Dec-11-2006 09:43
KilldaDJ
birth.school.trance.death
Registered: Sep 2001
Location: tranceaddict wants to know your location
Originally posted by KilldaDJ
it feeds the penus sexually provoking thoughts
Yeah
when farmacological companies show freaaky advs like
have the power to pour out the Nuclear fertlization
___________________
My TOP Now
4 Strings - Into The Night(Purple Haze Remix)
Abel Ramos - Aquarius (Randy Katana Mix)
Nautical Imagery - Distant Dreams
Duderstadt - Muhanjala(Sean Tyas Mix)
Eric Prydz – ‘Proper Education(Sebastian Ingrosso Remix)
Markus Schulz - Without U (Coldharbour Mix) [Vocal Deep Pro.]
Sean Tyas - Lift
Dec-11-2006 12:28
EXTREMUM
Senior tranceaddict
Registered: Aug 2006
Location: New York, USA
OMG, Viagra is the devil!!! Even though I have no erectile dysfunction, I tried it once for kicks, and it was hard for a few days straight. Since then, I've been getting erections at random times of the day, everyday. I'm a random walking tripod, for Christ's Sake! I suppose that's not a bad thing, unless you're at the office.
Last edited by EXTREMUM on Dec-11-2006 at 14:59
Dec-11-2006 14:34
grooviebeats
peanut butter jelly time
Registered: Jun 2003
Location: Jacksonville Fl
my dad took one once and his shit wouldnt go down. HE had to go to the hosp and they had to drain the blood in his penis throughout the day. They would drain it.. about 2 hours later it would be back to full stiffness again and repeat the process. Needless to say when he called me and told me he was in the hosp and why he was there i lol'd