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ok, don't panic.
First of all, you should update logic pro to 8.02 as well as your OS X to 10.5.3, which addresses a few issues with CPU performance in Audio apps such as Logic, Live... Update also all of your 3rd party plug-ins and VSTi's if you haven't done so yet.
Now, it's very important for you to know how permissions and optimizing can affect OS X.
In Applications> Utilities, there's Disk Utility. If you start it up and click on your Mac HD volume, you should see an option "repair disk permissions". Click on it. It might take a while until it's done. It solves a lot of issues that slow every read/write process down.
Now, Onyx. Google it, download this app, and run it, it's entirely free. Onyx proposes a bunch of maintenance processes that will empty caches, so everything should run smoothly. I do this every now and then and it helps, really.
You said that you're running Romplers such as Nexus... Glitching might be due to disk fragmentation if those romplers are installed on an external drive. I recommend using Speedtools or Techtool pro in that case. If you want to make sure, Disable Nexus when doing playback. It wouldn't surprise me at all.
Last thing, the minimum amount of buffers when using external interfaces such as M-audio's should be set to 256 or even 512 samples.
It's probably something like that. Can't be anything else.
Of course Tiger does eat up a lot less RAM, but I personally cannot live without Leopard's new features (Core-level VNC, Spaces, etc...)
Good luck
Laurent
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