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I have one and it works wonderfully fine. The only issues i had with it was when i placed my computer into stand by mode and the audio wouldn't register until i went into the control panel and changed the audio back to "Saffire 6 USB"
As for the USB 1.1, i was a bit weary on that as well when i was researching it. At least from what i read, 1.1 won't make such a major different due to the fact that you're not recording more than two inputs so the speed isn't needed.
My current setup has my KRK Rokit6 g2's running through it and an audio technica AT2020 for a mic. Haven't had any issues with it so far and it works fine for what i needed, a basic two input audio interface.
for the price, it's a steal for what it is. build quality is full on metal construction so it doesn't feel cheap. the only thing that does feel cheap would be the dial knobs but that's not much of an issue to me.
i was debating on buying one of the Lexicon's Ionix U42s but then when i played with it in person, it looks bland.
pick it up! can't go wrong with focusrite 
oh and yes, you can use ASIO with it. The only time when i use ASIO is when i'm recording with my mic.
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