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I love these questions - which is better? Halo 3, Icecream on a hot day or the Chicago Bulls?
Okay, it's not quite that random a question, but it's still a random question, since you haven't specified any parameters for discussion. What do you mean by "better", better in what way? Depending what you mean by that, the answer will be "yes", "no" or "makes no difference".
Each piece of software has pros and cons, some will be suited to some people better than others. For example, if you want to do a lot of audio recording and editing of the recorded waveforms, Cubase would be the better choice.
But Reason is totally self-contained, rock-solid, with drum machines, samplers, loop players, synths and heaps of sound processors. The file sizes are much smaller since you're not recording many channels of audio. There are many pluses, and Thor is a great synth, to my ears.
As some people have said, with Rewire you can use a combination of all the tools you like and make use of what they all do well, thus speeding up your workflow immensely. I'm currently using Cubase, with Reason and Live rewired into it. It doesn't have to be an "either-or" choice.
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