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Basically, if you put the speakers in parallel, it will half the impedance. Put them in series, and it will double.
Typically, an amp that delivers 250W at 8 ohms will deliver 500W at 4 ohms (I assume you're dealing with solid state here as opposed to tubes). Much below 4 ohms though, and the amp will shut off if it has circuit protection, as a short circuit will essentially be made due to the lack of resistance.
If the speakers operate at 8 ohms, then you should be able to put 2 sets in parallel and run the amp at 4 ohms. Should look like this:
S--S--Amp--S--S
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