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Yeah I don't really know too much about the pharmacokinetics and stuff like that man haha. You're taking a risk whatever you do, even if you're taking a prescription drug. I always tell people my health has been more adversely affected by prescription drugs than non-prescription drugs, and that's the truth. If you have a lot of allergies like me, some synthetic chemicals will really fuck you up!
My friend is in some rural shit town outside of Ft worth now, and it's been awhile since I've seen him. I think he's doing better now from what I've heard. I still think that if you're mentally unstable you should stay away from that kind of stuff, because you'll have a brain chemistry imbalance to begin with. I don't know about anything else.
Wait ya I do haha. I can tell you that with a psychoactive substance like coke, acid, pot, E etc. it "tricks" your brain into thinking it's a certain brain chemical or neurotransmitter. For example with cocaine, your brain can't tell the diff between teh cocaine molecule and the dopamine molecule. The cocaine molecules fit into the receptor sites for dopamine, and you get the same kind of feeling you would have if you had way too much dopamine. Over time your brain starts to produce less of its own dopamine, and/or it lessens the amount of dopamine receptor sites in an attempt to regain homeostasis (balance). This is what leads to tolerance and sometimes addiction. I'm pretty sure with E, your brain thinks it's the neurotransmitter serotonin, and it fits into the receptors for serotonin. So again, it wouldn't be too good for a depressed person to take that.
It's a similar thing like if you started taking hydrocortisone (or another hormone). Your adrenal glands stop making their own cortisol to try to regain a balance.
BTW, what's with all the drug posts today?? 
"I'm high on life, but I'm slowly building a tolerance..."
That should go in my sig 
Dave
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http://www.discoboomer.com/forums/
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jk
