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Depends on the software you are using.
For example in Cubase SX
- Launch SX first (the host needs to be launched first)
- Go in the device menu, if you got Reason installed, there should be something like Rewire Device
- Activate a desired number of Rewire channels (up to 64 I think)
- Launch Reason
You certainly have seen that hardware patch kinda module on top of reason, that has 64 outputs. In normal standalone mode, if you connect something to an output in that patch, the corresponding output of your soundcard is used. Now with Rewire active, those outputs don't designate a hardware output anymore, but a Rewire channel. I think by default the master out of the mixer is connected to 1 and 2. But it's perfectly possible to use your own setup. If you want a synth to get it's own channel in your host software, just connect it's outputs to that hardware patch. So for example, connect a Subtractor to channel 3 and 4, then Rewire channels 3 and 4 will be the sound of the Subtractor in Cubase.
Reason follows Cubase in most what you do. If you press play in Cubase, Reason will play, if you change tempo, dito...
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