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Nexus is a great VST. You won't only use it for leads, but if you buy 1 of the expansions at minimum you will see that the quality of the pads, pianos, synths and everything else is quite good. Nexus is made by Vengeance, the same company that puts out the sample packs. I know of several producers who were on ASOT Top 20 last year who use Nexus. Of course, you don't want to exclusively use Nexus by itself. A good producer has an abundance and a multitude of sounds. My best advice is to go into Nexus internally and design your own patches from scratch, or start with a preset and then design your patch from there. Never underestimate the internal workings because you can always tweak it out to get very unique and applicable sounds.
Presently I am using: Nexus, Rob Papen Blue (leads, sounds), Rob Papen Predator (basslines), and Spectrasonic's Trilogy (basslines) and GForce Minimonsta (A Moog Voyager emulation that is very fat and warm for basslines)
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