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I've had some bad anxiety from weed, but that didn't start to happen after years and years of use. I regret nothing, but I don't do it anymore. E, not so much.
Probably the most severe anxiety and paranoia I've had has been from psychoactive drugs, such as mushrooms. On the other hand, I've also had some incredibly positive experiences that have completely altered my perception of the world since then, for the better and worse.
There was one time where I was actually in my own room. My gf was with me, but there was such a distance between us, and the walls of the room were literally closing in on me. FOr about two hours I thought of nothing except whether I was sane enough to be able to call someone and ask for help if I actually ended up needing it.
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