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| quote: | Originally posted by gehzumteufel
was unaware of the neurotoxicity.
and whats DA/NE? |
dopamine/norepinephrine
| quote: |
Amphetamine treatment similar to that used in the treatment of adult attention-deficit/hyperactivity disorder damages dopaminergic nerve endings in the striatum of adult nonhuman primates.
Ricaurte GA, Mechan AO, Yuan J, Hatzidimitriou G, Xie T, Mayne AH, McCann UD.
Department of Neurology, Johns Hopkins Medical Institutions, 5501 Hopkins Bayview Circle, Rm. 5B.71E, Baltimore, MD 21224, USA. [email protected]
Pharmacotherapy with amphetamine is effective in the management of attention-deficit/hyperactivity disorder (ADHD), now recognized in adults as well as in children and adolescents. Here we demonstrate that amphetamine treatment, similar to that used clinically for adult ADHD, damages dopaminergic nerve endings in the striatum of adult nonhuman primates. Furthermore, plasma concentrations of amphetamine associated with dopaminergic neurotoxicity in nonhuman primates are on the order of those reported in young patients receiving amphetamine for the management of ADHD. These findings may have implications for the pathophysiology and treatment of ADHD. Further preclinical and clinical studies are needed to evaluate the dopaminergic neurotoxic potential of therapeutic doses of amphetamine in children as well as adults.
PMID: 16014752 [PubMed - indexed for MEDLINE]
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And it's neurotoxic in most mammals in dosages around 20mg/kg IV (a lot I know).
I haven't actually used an illegal drug in years, benefit of being a chemist I guess, you can have unscheduled drugs and prodrugs.. Not that I trust experimental drugs though, I rarely ever get high anymore, and I figure every now and then shouldn't hurt..
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Alcoholic Alliance
The Ecstasy (MDMA) Bible Thread 2.0
| quote: | Originally posted by Masonious
you win again dude - and nice move shoving the whole i figured out how to order pizza thing in my face. i tried that 4 and a half months ago and woke up with a Taiwanese transvestite but to Ygrene it's just, "anoother day in the life, noooo biggieee".
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