A surround sound enviroment actually pushes usual 2D music production into 3D. You don't have a wall of sound anymore, but a cube that needs to be sound engineered, by the producer, as well as the technician in the club to prevent unwanted interference.
An "easy" way to mix this type of music would be simply have a stereo downmix on your headphones. The basics of e.g. harmonic mixing shouldn't change, whether it's stereo or surround. The beat anyway would be a mono signal on the sub, disconnected from the surround set-up.
But the very best oppertunity such a system would offer is, in my opinion, the connection of light and sound! Since the light in a club enviroment is already used all around, it could now be connected to a surround sound. This would make dancing on the dancefloor like flying in a sphere of sound a light that is all around you.
The 2D analogy is a stereo system with videos played, which is already used, keyword VDJ.

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DJ Soulstone - Summer Solstice 2012 [Goa/Full-On]