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Bad drug bedtime stories
Its not the fact that he's "killed braincells", some probably died as a result, a bit like binge drinking.
Whats definately happened though is that he's altered his body chemistry, particually his nueral chemistry.
Parts of your brain are sensitive to pleasure and are stimulated with chemicals called endorphins, there are also others which affect seretonin levels and such to make your synapses work.
Sooooo, when a person takes enough of these artificial 'endorphins' to stimulate their brain the body says to itself-
"Hey I dont need to make endorphins anymore, theres a sea of them here."
So that little factory in your body goes out of business for a few months, little endorphin chemists in your body get a redundancy payout and given the sack.
Meanwhile, the sea of endorphins running amok in the body subsides and the body sort of says to itself again-
"Well, no. Not for awile, we have to train new endorphins so your just going to have to tough it out."
But kiddies, you body needs these endorphins regually otherwise you start loosing sleep, getting irritable, agressive and thinking about taking some more to supplement the lack of fun feeling chemical in your body. Eventually if the body either has a nice depressive episode until the juice starts flowing or you go back to drugs.
Lets not even mention what goes into drugs that are for sale on the street, yes, your friend the the drug dealer is a provider of street level quality drugs, no matter what BS he feeds you, after all youre a customer...
Fun additives to E's you may find-
Icing sugar 
Psuedoephidrine
clororpheniramine
hydrocloride
methamphetamine
All manner of fun things to make your heart go *pop*, drink lots of water, induce a psychotic episode or just plain wreck whatever common sense you had left.
As for someone taking 300 E's, I can say Im sympathetic to a person doing that to themselves because its just so damn stupid it has to be natures way of throwing chlorine in the gene pool.
Unfortunately they probably wont die and then the poor old tax payer has to foot the bill for another drug-addled idiot to sit in a rubber room painting the walls with their own feceal matter for the next 15-25 years.
Lucky me, Im so glad I pay taxes to clean up other peoples stupidity.
DrugNun 
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