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This medicine may make your skin more sensitive to the sun, which may lead to painful sunburns. While you are taking this medicine, avoid long exposure to the sun. Wear protective clothing, a hat, and sunscreen lotion when you need to be outdoors. Do not use a sunlamp. If you get a severe sunburn, contact your health care provider right away.
When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your health care provider if you are taking:
antacids (take them 2 hours apart from this medicine)
blood thinners such as clopidogrel (Plavix), ticlopidine (Ticlid), and warfarin (Coumadin)
cyclosporine (Neoral, Sandimmune)
HMG-CoA reductase inhibitors, such as atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor)
digoxin (Lanoxin)
dofetilide (Tikosyn)
drugs that interact with erythromycin
ergotamine (Ergomar) or dihydroergotamine (D.H.E. 45)
pimozide (Orap)
rifabutin (Mycobutin)
seizure medicines such as carbamazepine (Tegretol), phenytoin (Dilantin), and valproic acid (Depakote, Depakene)
tacrolimus (Prograf)
theophylline
triazolam (Halcion)
vinblastine (Velban, Velsar).
Overall, the most common side effects associated with treatment in adult patients who received IV/PO Zithromax were related to the gastrointestinal system with diarrhea/loose stools (4.3%), nausea (3.9%), abdominal pain (2.7%), and vomiting (1.4%) being the most frequently reported.
The most common side effects associated with treatment in adult women who received IV/PO Zithromax in studies of pelvic inflammatory disease were related to the gastrointestinal system. Diarrhea (8.5%) and nausea (6.6%) were most commonly reported, followed by vaginitis (2.8%), abdominal pain (1.9%), anorexia (1.9%), rash and pruritus (1.9%). When azithromycin was co-administered with metronidazole in these studies, a higher proportion of women experienced side effects of nausea (10.3%), abdominal pain (3.7%), vomiting (2.8%), application site reaction, stomatitis, dizziness, or dyspnea (all at 1.9%).
No other side effects occurred in patients on the multiple dose IV/PO regimen of Zithromax in these studies with a frequency greater than 1%.
Side effects that occurred with a frequency of 1% or less included the following:
Gastrointestinal: Dyspepsia, flatulence, mucositis, oral moniliasis, and gastritis.
Nervous System: Headache, somnolence.
Allergic: Bronchospasm.
Special Senses: Taste perversion.
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