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FYI if you give your rat ecstasy, don't play loud music. His comedown will suck
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| occrider |
| quote: |
Loud music worsens effects of taking ecstasy
Submitted by BJS on Thu, 2006-02-16 09:23.
Loud music prolongs the effects of taking ecstasy for up to five days. A study published today in the open access journal BMC Neuroscience shows that the reduction in rats' brain activity induced by 3,4 -Methylenedioxymethamphetamine (MDMA or ecstasy) lasts long after administration of the drug - up to five days - if loud music is played to them simultaneously. The effects wear off within a day when no music is played.
Michelangelo Iannone from the Institute of Neurological Science, Italy, and colleagues from University Magna Graecia in Catanzaro, Italy, injected rats with a low dose (3mg/kg) or a high dose (6mg/kg) of MDMA or, in the control group, with saline. The rats were either left without acoustic stimulation or exposed to white noise - sound at a stable frequency that is used in many types of electronic music. The sound was played at 95dB, the maximum noise intensity permitted in nightclubs by Italian law. The electrocortical activity (EcoG spectrum) of the rats was monitored, using electrodes placed on their skull, from 60 minutes before administration of the drug and start of the music, to up to five days after the music was stopped.
Iannone et al.'s results show that low-dose MDMA did not modify the brain activity of the rats compared with saline, as long as no music was played. However, the EcoG total spectrum of the rats given a low dose of MDMA significantly decreased once loud music was played. The EcoG spectrum of rats in the control group was not modified by loud music. High-dose MDMA induced a reduction in brain activity, compared with both saline and low-dose MDMA. This reduction was enhanced once the loud music was turned on and lasted for up to five days after administration of the drug. In rats that had been given a high dose of MDMA but had not been exposed to music, brain activity returned to normal one day after administration of the drug.
http://www.scienceblog.com/cms/loud...tasy_10045.html
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White noise huh? Would that be tiesto? |
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| weymouth |
| Would that mean that hardcore X users would essentially never come off the high if they continued to listen to music constantly? |
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| DJ RJT |
| quote: | Originally posted by occrider
White noise huh? Would that be tiesto? |
I lol'd in HARD at that... :) |
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| lücid |
| i only give my rats the best pills... they never complain about bad comedowns! :cool: |
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| Djshortcircuit |
| quote: | Originally posted by occrider
White noise huh? Would that be tiesto? |
ha, funny... real funny... |
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| paranoik0 |
| quote: | Originally posted by occrider
White noise huh? Would that be tiesto? |
:stongue:
tiesto joke of the month
as for the actual news, sorry but i decided to skip the rest as soon as i tried to spell Methylenedioxymethamphetamine. |
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| Boomer187 |
haha, I found the actually source article, hoping ot catch an error, which is usually present. But I could not find one in this article, nothing I could find in the methods section made me think twice aboutthe results...
....why...
THERE IS NO METHODS SECTION...WTF DID THEY DO!!!! |
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| MisterOpus1 |
| quote: | Originally posted by Boomer187
haha, I found the actually source article, hoping ot catch an error, which is usually present. But I could not find one in this article, nothing I could find in the methods section made me think twice aboutthe results...
....why...
THERE IS NO METHODS SECTION...WTF DID THEY DO!!!! |
I took a peak and sure enough you're right. Over at PubMed:
| quote: | BMC Neurosci. 2006 Feb 16;7(1):13 [Epub ahead of print] Related Articles, Links
Electrocortical effects of MDMA are potentiated by acoustic stimulation in rats.
Iannone M, Bulotta S, Paolino D, Zito MC, Gratteri S, Costanzo FS, Rotiroti D.
ABSTRACT: BACKGROUND: 3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) is known for its toxicological, psychopathological and abuse potential. Some environmental conditions, e.g. acoustic stimulation typical of the "rave scene" can influence the toxicity of this drug. RESULTS: We investigated the effects of low doses of MDMA in vivo using Wistar rats in the absence of acoustic stimulation (white noise; 95 Db) demonstrating that ecstasy is able to induce a significant activation (reduction of Electrocortical total power) of the telencephalic cortex that spontaneously reverts in the absence of sensorial stimuli, whereas it persists for several days if, in addition to MDMA, the animals are exposed to acoustic stimulation. CONCLUSIONS: Our data demonstrate that low doses of MDMA are able to reduce electrocortical total power, and that this effect is potentiated by sensorial stimuli commonly present in certain environments, such as rave parties.
PMID: 16480519 [PubMed - as supplied by publisher] |
Methods? We don't need no stinkin' methods!!! Hopefully my school library will have this in print soon.
Occ, whadaya doin' here, bub? Come on back to the PDD. I promise I'll strike up an evolution/creationism argument with someone if you come......... |
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| occrider |
| quote: | Originally posted by MisterOpus1
Occ, whadaya doin' here, bub? Come on back to the PDD. I promise I'll strike up an evolution/creationism argument with someone if you come......... |
Lies. There are no fun, religious fundies in there anymore. Only adolescent, political fundies who seem to make my blood pressure spike when I go in there :p. |
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| Boomer187 |
| quote: | Originally posted by MisterOpus1
I took a peak and sure enough you're right. Over at PubMed:
Methods? We don't need no stinkin' methods!!! Hopefully my school library will have this in print soon.
Occ, whadaya doin' here, bub? Come on back to the PDD. I promise I'll strike up an evolution/creationism argument with someone if you come......... |
The full text article is here
they shouldn't allow articles that do not include a methods section, how are we suppose to reproduce this. |
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