anybody know the shelf life of e??

DON'T CHEW, PARACHUTE.

DONT CHEW THEY TASTE GASH!

If you're shoving pills in your penis and up your ass, I think you have some major drug issues you need to deal with.

omg penis

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Originally posted by Mike_B k i dunno where your getting your info. But stamps really don't mean much. Someone producing the pills makes one batch and puts a stamp on it. This may last like 3months tops, then he's out he's gotta make more, the next one regardless if he puts the same stamp on it will probably not be 100% the same. And that's even if he uses the same formula and decides to put in the same mixtures of drugs and so on, which he probably wont. And another thing. look at the size of the pill you are taking. its very small. about 125milligrams. and that's a big pill too. coke most ppl might do like half a gram to one gram a night, easy. And the buzz on coke really only last about 30minutes, and E buzz last like 4-6 hours depending on how you take it. So once again. Explain to me how you find a good pill of e with coke in it. Makes NOOOOOOOOOOOO SENCE

i agree with you. i was just passing on information and playing a bit of devil's advocate.

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Originally posted by Mike_B The feelings you get from an E buzz comes not from MDMA, but from the serotonin

Its a bit more complicated than that.
MDMA binds at the serotonin, norepinephrine (noradrenaline), dopamine, and acetylcholine receptors, and at the serotonin and dopamine transporters (Rivas-Vazquez, Delgado, 2002). It moves through the serotonin pathway, to the cell bodies in the Raphe nucleus and sends long axons to the neocortex, and the limbic system, and also descends the spinal cord to affect the motor neurons (NIDA, 2003).
MDMA's primary mechanism of action is by releasing 5-HT (serotonin)and blocking its reuptake (Palfai, Jankiewicz, 2001). It also increases the net release of norepinephrine, and dopamine, and blocks the reuptake of dopamine (Rivas-Vazquez, Delgado, 2002). MDMA stimulates serotonin efflux from plasma membrane vesicles and secretory vesicles (Rudnick, Wall, 1992). In the plasma membrane vesicles, MDMA inhibits serotonin transport by direct interaction with the sodium dependent transporter. MDMA inhibits ATP-dependent serotonin accumulation and stimulates efflux of previously accumulated serotonin (Rudnick, Wall, 1992). Usually after serotonin is released into the synaptic gap and is used, serotonin transporters move serotonin back into the presynaptic neuron to be metabolized. MDMA prevents the transporters from taking serotonin back into the presynaptic neuron. It can also cause the transporters to work in reverse bringing serotonin into the synaptic gap (NIDA, 2003).
http://www.humboldt.edu/~morgan/mdma_s03.htm

chewing never lead to numbness for me, neither did sucking on them though that was just painfully disgusting. i dont think i noticed a dramatic difference in the "high" or the plateau of the "high" by the different intake methods either.
damnit, it's a pill ,it's just meant to be swallowed in the end.

drugs drugs DRUGS DRUGS DRUGGGSSSSSSS!!!!!

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I prefer insufflation or just eating the ******s by themselves. No chewing or sucking for me. Though crush/blow sure hurts like the devil.

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Originally posted by DJ-Fuq Its a bit more complicated than that.

you actually thought me a few things there, but most of that i knew, i oversimplified it just to prove the point that shoving mdma in your mouth or smashing in on your forehead isn't gonna make you high.

Also while were on the subject, maybe you have greater insight on what actually causes damage and how much mdma you can take at once or how long in between uses you should wait.

Based on what i could come up with, the damage is not cause by MDMA, but by your brain running out of serotonin, the ruptakes transporters of the serotonin neurons then start taking in Dopamine which has also been released into the cell. This would usually not occur because of an abundance of serotonin present in the synapse. Once inside the serotonin cells dopamine is broken down into two separated enzymes, one of which is actually toxic to the cell.

I figured, if you took a small amount of E, and 5-htp supplyments and only did it once and a while, like once every two months or so. You can minimize the damaged cause.

anyways, anymore thoughts on that?

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Originally posted by Mike_B you actually thought me a few things there, but most of that i knew, i oversimplified it just to prove the point that shoving mdma in your mouth or smashing in on your forehead isn't gonna make you high. Also while were on the subject, maybe you have greater insight on what actually causes damage

http://www.macalester.edu/~psych/wh.../dopamine2.html
That explains it pretty well.

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and how much mdma you can take at once or how long in between uses you should wait.

I dont know I think the most anyone really knows is the less u take the safer u are.

quote:

Based on what i could come up with, the damage is not cause by MDMA, but by your brain running out of serotonin, the ruptakes transporters of the serotonin neurons then start taking in Dopamine which has also been released into the cell. This would usually not occur because of an abundance of serotonin present in the synapse. Once inside the serotonin cells dopamine is broken down into two separated enzymes, one of which is actually toxic to the cell.

"When dopamine is taken into the serotonin axons it will damage them. The axons are initially damaged by dopamine itself and then damaged by the byproduct that is produced when it is broken down by MAO (monoamine oxidase). Thus, the prevailing theory of the neurotoxic nature of MDMA is that dopamine is allowed to enter into the serotonin axons because of MDMA's inhibition of serotonin reuptake. The dopamine then works as a toxic element, ultimately destroying the serotonin neuron." (quote from the link)

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I figured, if you took a small amount of E, and 5-htp supplyments and only did it once and a while, like once every two months or so. You can minimize the damaged cause. anyways, anymore thoughts on that?

U might wanna read this:
http://www.erowid.org/chemicals/mdm..._article3.shtml