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how does LSD work?
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| UglyDave |
from taking a tiny little piece of paper, it give u all this crazy .
where do all the thoughts come from?
what does it actually do? |
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| albertoR |
From: Lamont Granquist
Newsgroups: alt.rave
Subject: Re: LSD The facts!
Date: 31 Aug 1992 02:43:19 GMT
THE FACTS.
I don't have this thing referenced, I don't have anywhere near the time...
LSD does not cause any chronic physiological or neurological damage. period.
LSD does not produce a psychotic state. LSD is not a psychotomimetic
drug in the literal use of the word. I've experienced true drug psychosis
before, and LSD just ain't close...
LSD may produce chronic visual "tracers" -- probably as a result of receptor
changes in the sensory pathways of the brain. This is not damage. Some
people have these naturally, particularly in the morning. I've gotten
them from prescription drugs, which caused this and enhanced my vision at
the same time (QED, I'm not complaining...).
LSD may cause mild "flashbacks" (IMHO a misuse of the word) which is really
just state-dependent learning. Users sometimes can get themselves into a
slightly shifted perspective when a stimulus is similar to one experienced
while on LSD, or if one is familiar enough with the LSD state they can
sometimes create this mild perspective shift themself.
LSD may produce thick chronic visual "tracers" which interfere with vision.
This is very rare, and is not "damage" per se since it is reversible with
drug therapy (probably neuroleptics, but I'm not positive). Most users if
they report anything report the benign type.
LSD may produce a sydrome resembling Post Traumatic Stress Disorder. This
is due to a massively bad trip... Here is where you get your honest-to-god
flashbacks from. Its also not very common.
LSD may produce a schizophrenic break in someone already suscpetible to
schizophrenia, again due to the psychological trauma of an extraordinarly
bad trip. This, however, is a case of "if it didn't happen on LSD, it
would've happened at some point".
The frequency of the above three chronic effects is less than 2:1000 which
is about the same as the *normal* frequency of schizophrenia in the
population. Conclusion: normal people that drop LSD remain normal people,
people with schizophrenic tendencies or other psychological disorders get
more ed up. And I bet the guy who was distributing that pamphlet on the
evils of LSD probably had a schizophrenic break which is why he was so
damn concerned with it changing your personality... |
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| DJ Nuclear |
LSD a is lysergic acid diethylamide 25, a tryptamine. LSD works by upsetting upsetting serotonin balance in the 5-HT-2A/5-HT-2C receptor areas of the brain. The receptor area primarily responsible for hallucinations is the 5-HT-2A one. Scientists are currently unsure why playing around with this site will trigger hallucinations, as it doesn't seem to control any other functions in the brain save for causing hallucinations when it is upset (a lot of the receptor sites control things like gag reflex, automated physical responses, etc).
So simply: a tiny amount of LSD (all that's needed for hallucinations) comes in, messes around mainly with a couple small receptor sites in the brain and causes them to function abnormally, and this causes you to hallucinate. |
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| UglyDave |
| quote: | Originally posted by DJ Nuclear
So simply: a tiny amount of LSD (all that's needed for hallucinations) comes in, messes around mainly with a couple small receptor sites in the brain and causes them to function abnormally, and this causes you to hallucinate. |
k, feel like a tard for askin this, but receptors are things which pick up signals??
or: when nutrients / all sorts of go to ur brain, are the receptors the things which soak it all up? |
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| Floorfiller |
| quote: | Originally posted by UglyDave
k, feel like a tard for askin this, but receptors are things which pick up signals??
or: when nutrients / all sorts of go to ur brain, are the receptors the things which soak it all up? |
receptors pick up and transmit the signal....wait...i dunno i'm not premed...just a thought... |
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| DJ Nuclear |
| It's the receptors in the sites which are affected, and the sites consist of a whole lot of receptors, with neurotransmitters like serotonin to keep them functioning correctly. As far as I understand, neurotransmitters are used by the neurons, who take in the transmitters and fire electric impulses based on them. |
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| Mako |
| Receptors are gated proteins on the cell surface of your neurons. There are connections between your neurons, called synapses which are essentially gaps, where electrical signals from one neuron passes to the end of a neuron at the synapse and induces the release of neurotransmitters i.e. serotonin; the receptors pick this up as a "message" and transmit the "message" to the neuron. Now drugs like LSD and e mess around with those receptors. Not going into details of how they do it. Too lazy. lol. |
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| DJ Nuclear |
| quote: | Originally posted by Mako
Receptors are gated proteins on the cell surface of your neurons. There are connections between your neurons, called synapses which are essentially gaps, where electrical signals from one neuron passes to the end of a neuron at the synapse and induces the release of neurotransmitters i.e. serotonin; the receptors pick this up as a "message" and transmit the "message" to the neuron. Now drugs like LSD and e mess around with those receptors. Not going into details of how they do it. Too lazy. lol. |
Neurotransmitters are taken into the cells as well, and the cell decides to re-release them (re-uptake, I think), or break them down and get rid of them. |
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| Mako |
| quote: | Originally posted by DJ Nuclear
Neurotransmitters are taken into the cells as well, and the cell decides to re-release them (re-uptake, I think), or break them down and get rid of them. |
Yes re-uptake or breakdown occurs by an enzyme called Mono Amine Oxidase (MAO), and this is where anti depressants like prozac (an MAO inhibitor) comes into play. :D |
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| Flyboy217 |
| quote: | Originally posted by Mako
Yes re-uptake or breakdown occurs by an enzyme called Mono Amine Oxidase (MAO), and this is where anti depressants like prozac (an MAO inhibitor) comes into play. :D |
Actually, Prozac is an SSRI (Selective Serotonin Reuptake Inhibitor). SSRIs work by preventing neurons from reuptaking serotonin (hence the name, of course). The job of MAO is to break down monoamine neurotransmitters (including serotonin, epinephrine, and norepinehprine). Both MAOIs and SSRIs serve to increase serotonin levels. Combining them can lead to Serotonin Syndrome, which can be fatal.
Other reuptake inhibitors include cocaine (for dopamine, to make you feel goooood) and Donepezil (for acetylcholinesterase, to treat Alzheimer's). |
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| Mako |
| quote: | Originally posted by Flyboy217
Actually, Prozac is an SSRI (Selective Serotonin Reuptake Inhibitor). SSRIs work by preventing neurons from reuptaking serotonin (hence the name, of course). The job of MAO is to break down monoamine neurotransmitters (including serotonin, epinephrine, and norepinehprine). Both MAOIs and SSRIs serve to increase serotonin levels. Combining them can lead to Serotonin Syndrome, which can be fatal.
Other reuptake inhibitors include cocaine (for dopamine, to make you feel goooood) and Donepezil (for acetylcholinesterase, to treat Alzheimer's). |
Ahhh i thought it was an MAOI. Heh didn't know about the drugs that much. Oh well, learnt something new. |
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| smokeape |
Don't know what LSD is these days after Mr Natural many moons ago. I know it will f*ck you up and lingers a while. Be careful not to let your bud take another hit because "nothing's happening." Lol, just wait and you won't know anyway because you're not really aware of what it's doing. DON'T DO IT ALONE!!!!! Make sure someone's around to keep you from doing something really stupid. I've seen people do some stupid sh*t.
;)
[[[smoke]]] |
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