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Pot has became totally annoying (pg. 6)
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| lex400sc |
| people who say weed makes them feel weird or paranoid or scared or even just really out of it.... IT'S ALL ABOUT MINDSET! it takes some practice but you have to learn to take control the high and not let the high take control of YOU. once you do that, you can get high and go to court, get high and give public speeches, get high and go to a job interview, get high and do whatever the hell you want and it'll be that much funner... |
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| L.E.N. |
| I was a functional smoker...I just tapered off from it...I actually like when it gets weird...for a long time I smoked so much that I felt I needed it...now its so overwhelming (in a good way). More bang for the buck...I just dont smoke when I wakeup I wait till Im off work. So I can enjoy it. |
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| Nrg2Nfinit |
| quote: | Originally posted by E-xperienceXTC
Is there any proof that ecstacy depletes all/most of your seratonin?
cause I took E back to back days somethimes and the second day I was still rolling. And some people on this board say it takes a couple weeks to get your seratonins back. |
its not about the seratonine which can be easily synthesized in your body by taking tryptophan --> 5 HT --> seratonin (metabolic pathway). The receptor disapearance (gateways to which seratonin is transmitted from neuron to neuron) occurs causing less seratonin to be utilized. So in essence you can get all the seratonin you want by taking tryptophan, but if the receptor pathways are not available, there is no way the neurotranmitter can pass from neuron to neuron. 5 HT can be increased by supplementing benzodiazepine (an antidepressant) which will cause more receptors to be available. These drugs must be administered chronically as once they are stopped a chemical imbalance in the brain will occur. you can get your seratonin back, you can get your 5 HT back but everything must be in good working order for your brain to function properly.
Youd have to take alot of extacy for a prolonged period of time and hten just suddenly stop. The side effects are motor skills loss, hallucinations and anything related to schitzophrenia and parkinsons disease |
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| lex400sc |
| quote: | Originally posted by E-xperienceXTC
Is there any proof that ecstacy depletes all/most of your seratonin?
cause I took E back to back days somethimes and the second day I was still rolling. And some people on this board say it takes a couple weeks to get your seratonins back. |
mdma allows dopamine to plug into serotonin reuptake sites, which is in turn broken down into hydrogen peroxide... aka: antibiotic disinfectant, aka: hair bleach. do you think hair bleach does good things inside your brain?
the one way to counter this process is by taking prozac within 6 hours of dropping, however prozac will effectively kill your high the minute it's absorbed. |
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| igottaknow |
| i only smoke on special occasions. if u need to do drugs everyday something is wrong with you and your life |
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| Nrg2Nfinit |
| quote: | Originally posted by lex400sc
mdma allows dopamine to plug into serotonin reuptake sites, which is in turn broken down into hydrogen peroxide... aka: antibiotic disinfectant, aka: hair bleach. do you think hair bleach does good things inside your brain?
the one way to counter this process is by taking prozac within 6 hours of dropping, however prozac will effectively kill your high the minute it's absorbed. |
that is wrong
i dont know whwere you read this..
mdma is the drug that blocks reuptake which inturn causes an excessive amount of dopamine and seratonin inbetween synaptic terminal buttons. post synaptic receptors thus receive higher amounts of dopamine and seratonin causeing faster firing of neurons (more neurotransmitter transmitted). at the end there is a depletion of dopamine and seratonin at these sites causing a loss of there neurotransmitters, less firing causing slowed symptoms equivalent to a comedown.
taking prozac will help alleviate these symptoms temporarily, but in the end it will cause symptoms similar to those of a comedown if not administered chronically. so basically you might as well just take more extacy LOL.
I made a mistake, benzodiazepine is a relaxant which acts as an agonist for 5HT opening up more receptor pathways. this will help alieviate a comedown, as seratonin will be able to be transmitted more easily from neuron to neuron. |
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| Nrg2Nfinit |
| quote: | Originally posted by igottaknow
i only smoke on special occasions. if u need to do drugs everyday something is wrong with you and your life |
people who are bi poplar ADD and depressed need to take medication chronically. the sad news is once they get off these medications, their original symptoms are much worse then they were initially. |
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| igottaknow |
| quote: | Originally posted by Nrg2Nfinit
people who are bi poplar ADD and depressed need to take medication chronically. the sad news is once they get off these medications, their original symptoms are much worse then they were initially. |
i meant taking recreation drugs on a regualar basis not stuff you need for physical or mental medical conditions. |
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| lex400sc |
| quote: | Originally posted by Nrg2Nfinit
that is wrong
i dont know whwere you read this..
mdma is the drug that blocks reuptake which inturn causes an excessive amount of dopamine and seratonin inbetween synaptic terminal buttons. post synaptic receptors thus receive higher amounts of dopamine and seratonin causeing faster firing of neurons (more neurotransmitter transmitted). at the end there is a depletion of dopamine and seratonin at these sites causing a loss of there neurotransmitters, less firing causing slowed symptoms equivalent to a comedown.
taking prozac will help alleviate these symptoms temporarily, but in the end it will cause symptoms similar to those of a comedown if not administered chronically. so basically you might as well just take more extacy LOL.
I made a mistake, benzodiazepine is a relaxant which acts as an agonist for 5HT opening up more receptor pathways. this will help alieviate a comedown, as seratonin will be able to be transmitted more easily from neuron to neuron. |
that is wrong
i dont know whwere you read this..
3,4-methylenedioxymethamphetamine has been shown to induce long-term deficits in serotonergic function in animal models. Several studies have suggested that dopamine (DA) uptake into serotonin (5-HT) terminals by the 5-HT reuptake transporter (SERT) and subsequent deamination by monoamine oxidase-B (MAO-B) leads to the formation of hydrogen peroxide and may be major contributors to this serotonergic toxicity. In the present study, when human choriocarcinoma (JAR) cells were exposed to MDMA (1.2mM) for 6h, followed by treatment with DA (0.1mM), hydrogen peroxide production increased over a 24h period, peaking at 420% over baseline and decreasing cell viability by 30%. DA alone increased hydrogen peroxide production 84% over baseline, but did not significantly decrease cell viability. Incubation of MDMA treated cells with the SERT inhibitor, fluoxetine (500nM) or the MAO-B inhibitor, l-deprenyl (0.1mM) for 30min prior to DA, significantly blocked free radical production and cell death. These findings support the hypothesis that the deamination of DA by MAO-B within the serotonergic cell can lead to hydrogen peroxide formation and ultimately cell death. |
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| colonelcrisp |
| quote: | that is wrong
i dont know whwere you read this..
3,4-methylenedioxymethamphetamine has been shown to induce long-term deficits in serotonergic function in animal models. Several studies have suggested that dopamine (DA) uptake into serotonin (5-HT) terminals by the 5-HT reuptake transporter (SERT) and subsequent deamination by monoamine oxidase-B (MAO-B) leads to the formation of hydrogen peroxide and may be major contributors to this serotonergic toxicity. In the present study, when human choriocarcinoma (JAR) cells were exposed to MDMA (1.2mM) for 6h, followed by treatment with DA (0.1mM), hydrogen peroxide production increased over a 24h period, peaking at 420% over baseline and decreasing cell viability by 30%. DA alone increased hydrogen peroxide production 84% over baseline, but did not significantly decrease cell viability. Incubation of MDMA treated cells with the SERT inhibitor, fluoxetine (500nM) or the MAO-B inhibitor, l-deprenyl (0.1mM) for 30min prior to DA, significantly blocked free radical production and cell death. These findings support the hypothesis that the deamination of DA by MAO-B within the serotonergic cell can lead to hydrogen peroxide formation and ultimately cell death. |
STFU noob. stop using big words to sound smart.... first of all Nrg2Nfinit knows his in this dept. ill vouch for that, i go to uni with him...
and beyond that fact, him and i have done a piss load of E in the past.... so i would consider ourselves experts in the field as it were lol.... |
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| ivanbee |
| long term use of E will make you ing retarded. same goes for pretty much any other drug |
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| ivanbee |
| quote: | Originally posted by colonelcrisp
and beyond that fact, him and i have done a piss load of E in the past.... so i would consider ourselves experts in the field as it were lol.... |
no wonder you're retarded:rolleyes: |
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