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Teens using Salvia Divinorim (pg. 4)
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| Electrophile |
| quote: | Originally posted by euclid
Apologies, my error.
Trust me, I don't need any help with IUPAC notation. :) Thanks though, it's good info to include.
The only thing I know of that's special about the methoxy group in these substances is it's a moderate electron withdrawing group in the same position as the normally activating HO group on serotonin, and thus has a rather interesting correspondance with receptor affinity. |
Hmmmm, I read this and now I have an idea. The whole EWG may change the polarity enough to allow it to pass all of the brains exterior wall or barriers if you will. Just a thought, but it is late and I have work in the morning! I will grab a book and read up tomorrow after work and get back to you. |
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| euclid |
| quote: | Originally posted by Electrophile
Trick question ;) I wanted to make sure you aren't some kid making stuff up LOL. |
Ah, a trick. ;) You did have me somewhat curious.
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Hmmmm, I read this and now I have an idea. The whole EWG may change the polarity enough to allow it to pass all of the brains exterior wall or barriers if you will. Just a thought, but it is late and I have work in the morning! I will grab a book and read up tomorrow after work and get back to you.
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There are, what, like 15 different serotonin receptor subgorups with different ligands? The balance of bias for different receptors is likely what accounts for for the differentiation in effect, although the potency would likely also be related to the polarity of the molecule, as you suggest. Let me know what you find out.
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The only thing obvious to me is that the 5-MeO is the positional analogue of the 4- substituent in phenethylamines. But then again any 5-___oxy has potential as a psychoative substance.
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Yeah, I suppose that any weaker EWG in that position could possibly have an interesting effect on which ligands the molecule decides to cooperate with, so long as it's not "too big to fit in the receptor", as it were. Although I must say that I haven't read any research in this area. Do you know if any of these have been investigated? |
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| PaulCky411 |
what the hell do you guys do for work??
i just read all of that and i'm guessing that you must have been studying for a while to know all of that stuff off the top of your head
- i have absolutely zero knowledge of chemistry, but lately i've been thinking about buying some books because i'm highly interested for some reason... |
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| jacklodestar |
| Correction: IT290 is alpha methyl tryptamine not 5-methoxy-alphamethyltryptamine big big difference in effects and dosage. 5-methoxy-N,N-diisopropyl-tryptamine (5-meo-dipt) is totally different as well. Valluim, Xanax, Clonepin, all tend to end the trip abruptly or greatly inhibit the vissuals. In refference to 5-meo-amt being pleasent,.....at 500 mq or 1 mg yeah maybe vaguely,...the lines that I've snorted (600 mg's weighed on a ohaus mg scale) were extreamily painful on the body and wildly out of control in comparison to any trip I've ever had before. Although I've never had a bad trip on 5-meo-amt it is an outterly insane trip at the dose(s) I took and don't reccomend anyone do it as people have died from less than 5o mg's of that . You get like a paraplegic on 5-meo-amt and the physical side effects resemble strycnine poisioning as the muscles contract and it contorts the body,...also the way you vommit on this stuff,...man the first time I took it I actually was afraid I might die,...and it wasn't without merit to be concerned as many have died experimenting with this substance. |
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| jacklodestar |
SWIM is an old "Bee" and attended U.S.F. in tampa, FL. SWIM also suspects euclid is a fellow "Bee" as well. SWIM only understands lab proceedure extreamily well.
As for me I'm getting out of the navy and worked as an E.O.D. So I understand a lot about the chemistry of explosives and have worked with the DEA and heard them running their mouths about "opperation web tryp" on occasion. |
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| Electrophile |
| quote: | Originally posted by jacklodestar
SWIM is an old "Bee" and attended U.S.F. in tampa, FL. SWIM also suspects euclid is a fellow "Bee" as well. SWIM only understands lab proceedure extreamily well.
As for me I'm getting out of the navy and worked as an E.O.D. So I understand a lot about the chemistry of explosives and have worked with the DEA and heard them running their mouths about "opperation web tryp" on occasion. |
Electrophile likes to keep his credentials and affiliations private aside from those that know him on a personal level outside of TA. Don't give out too much information to strangers on a public forum. |
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| Lomeli |
| No joke, this thread makes me want to study chemistry. |
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| jacklodestar |
| Thanks for the reminder. SWIM=Someone who isn't me. I don't give a though as I'm getting kicked out anyway for smokin up while I was over in Iraq and have nothing but utter disgust and shame for the people I served and worked with. However I would never engadge in any illcit activities as it's on the record I gave those up years ago. When I used 5-meo-amt and 5-meo-dipt, and well as IT290 (alpha-methyl tryptamine) they were legal and not even available through the internet. If your interested in chemistry go get a book and learn about it. |
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| Lomeli |
| What books would you recommend to get me started? |
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| Clovis |
| quote: | Originally posted by Electrophile
Have you ever messed with anything from the 2-C family? They are very strange and powerful as well. If you are looking for a short lived dramitc experience then I suggest dimethyltryptamine (DMT) or also called "businessman's lunch" because you can travel to a land far far away and be back to reality in 30 minutes. |
Havn't, although I hear they're alot of fun. Bas enjoyed some to Sasha @ Aalon and he had a good time for the most part.
Oh and DMT that just sounds bad :p |
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| jacklodestar |
| The Organic Chem Lab Survival Manual by James W. Zubrick & Total Synthesis II by Strike if your looking to make primarily simple phenylethylamines,....anything else your going to need to take some chemistry courses at your local community college or what not. I would reccomend taking the coarses first as it will save you time, and a hell of a lot of money and probably save you from hurting yourself. |
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| jacklodestar |
| DMT scares me because it's produced naturally in the body at two points durring a humans life: once at conception (birth) and once at death. I used it once and was around bad people so maybe that's why I didn't enjoy it but for me it's something I don't like playing with for spiritual reasons. Has anyone tried methylone or 5-meo-mipt? |
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